NOAEL Data Cosmetic Ingredient

Oil of eucalyptus

Also known as: Eucalyptus oil, Oils, eucalyptus, Caswell No. 618A, EPA Pesticide Chemical Code 040503, Eucalyptus absolute (+13 more)

CAS 8000-48-4

Oil of eucalyptus (CAS 8000-48-4) is a chemical substance. Key regulatory status: 41 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) →

SOURCE noael studies public
NOAEL studies
23
SOURCE chemical inventory jurisdictions
Regulatory lists
41
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
Oil of eucalyptus
CAS Number
8000-48-4
DTXSID
DTXSID9034781
Synonyms
Eucalyptus oilOils, eucalyptusCaswell No. 618AEPA Pesticide Chemical Code 040503Eucalyptus absoluteEucalyptus citriodoraEucalyptus citriodora distillateEucalyptus globulus oilEucalyptus oil citriodoraFEMA No. 2466Oil eucalyptus globulus or macarthuriEssential oils, eucalyptus

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragranceDeodorizerHumectantSoftener and conditionerBiocidePharmaceutical

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 41 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
IFRA TransparencyIFRAIFRA
IFRA TransparencyIFRAIFRA
IFRA TransparencyIFRAIFRA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; Personal care - body oilDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - linimentDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
Canada; pharmaceuticalDrugBankDrugBank
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 23 of 23 studies
ValueUnitEndpointRouteSpeciesSource
100mg/kg bw/day--ratUnifiedCodex:CIR:beta.noael_studies
2R04ONI662UNIIFDA UNII substance identifier--openFDA substances
2R04ONI662UNIIFDA UNII substance identifier--openFDA substances
2R04ONI662UNIIFDA UNII substance identifier--openFDA substances
2R04ONI662UNIIFDA UNII substance identifier--openFDA substances
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
6480ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
=100mg/kg bw/dayNOAEL-ratCIR_vision_codex
=100mg/kg bw/dayNOAEL-ratCIR_vision_codex
=100mg/kg bw/dayNOAEL-ratCIR_vision_codex
=100mg/kg bw/dayNOAEL-ratCIR_vision_codex
=300mg/kgNOAELoralratCIR_vision_codex
=300mg/kgNOAELoralratCIR_vision_codex
=300mg/kgNOAELoralratCIR_vision_codex
=300mg/kgNOAELoralratCIR_vision_codex
=1000mg/kgNOAELoralratCIR_vision_codex
=1000mg/kgNOAELoralratCIR_vision_codex
=1000mg/kgNOAELoralratCIR_vision_codex
=1000mg/kgNOAELoralratCIR_vision_codex
3unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization
300mg/kgoral toxicityoralratUnifiedCodex:CIR:beta.noael_studies
300mg/kg/dayoral toxicityoralratUnifiedCodex:CIR:beta.noael_studies
1000mg/kgoral toxicityoralratUnifiedCodex:CIR:beta.noael_studies

Showing 23 of 23 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
26
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Oil of eucalyptus?

Oil of eucalyptus has 23 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in rat. Source: UnifiedCodex:CIR:beta.noael_studies.

What regulatory lists include Oil of eucalyptus?

Oil of eucalyptus appears on 14 regulatory/inventory lists including IFRA Transparency, consumer_product, Europe; Personal care, and 11 more. Source: EPA CPDat.

Is Oil of eucalyptus used in cosmetics?

Yes, Oil of eucalyptus is also indexed as a cosmetic ingredient under the name Eucalyptus Oil (Eucalyptus Globulus Leaf Oil). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Oil of eucalyptus come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Oil of eucalyptus used outside industrial chemicals?

Oil of eucalyptus also appears in cosmetics, pharmaceutical, food safety databases.