Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine (CAS 288254-16-0) is a cosmetic cosmetic ingredient functioning as UV absorber (optical brightener / UV light stabilizer); trade name Uvasorb K2A. Reported NOAEL =1400 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
US NotesNot FDA-approved as an OTC sunscreen active (not in 21 CFR 352); may be used as a product stabilizer, not as a sunscreen active
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine.
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Toxicological Studies
4 study endpoints found for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=1400 mg/kg bw/day
oral
rat
repeated dose toxicity
SCCNFP_vision_codex
NOAEL
=1400 mg/kg bw/day
oral
rat
repeated dose toxicity
SCCNFP_vision_codex
NOAEL
=1400 mg/kg bw/day
oral
rat
repeated dose toxicity
SCCNFP_vision_codex
NOAEL
=1400 mg/kg bw/day
oral
rat
repeated dose toxicity
SCCNFP_vision_codex
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine.
Is Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine safe in cosmetics?
Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Is Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine allowed in the EU?
Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine do in cosmetics?
Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine functions as: UV absorber (optical brightener / UV light stabilizer); trade name Uvasorb K2A. It is classified as a cosmetic ingredient in our database. CAS number: 288254-16-0.
What is the NOAEL for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine is =1400 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: SCCNFP_vision_codex.
Compliance Tools
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