Is Ethylene Carbonate safe in cosmetics?
Ethylene Carbonate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Ethylene Carbonate
Also known as: 1,3-Dioxacyclopentan-2-one, Dioxolone-2, EINECS 202-510-0, Ethylene carbonic acid, Ethylene glycol, cyclic carbonate (+2 more)
INCI: ETHYLENE CARBONATE
Ethylene Carbonate (CAS 96-49-1) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 96-49-1 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3-dioxolan-2-one
InChIKey
KMTRUDSVKNLOMY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — not specifically restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylene Carbonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethylene Carbonate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Ethylene Carbonate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethylene Carbonate by CAS number or substance name.
Studies
21
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
2216 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
1,3-Dioxacyclopentan-2-one
Dioxolone-2
EINECS 202-510-0
Ethylene carbonic acid
Ethylene glycol, cyclic carbonate
Ethylenester kyseliny uhlicite
UNII-RGJ96TB7R7
Chemical Function
Solvent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3181803
Frequently Asked Questions
Is Ethylene Carbonate allowed in the EU?
Ethylene Carbonate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Carbonate do in cosmetics?
Ethylene Carbonate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 96-49-1.
Is Ethylene Carbonate used outside cosmetics?
Ethylene Carbonate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethylene Carbonate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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