Moderate Cosmetic Ingredient Sensitization Data

Ethyl Cinnamate

Ethyl Cinnamate (CAS 103-36-6 [^1_10]) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; No specific technical function; UV. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.

View industrial chemical safety profile for CAS 103-36-6 [^1_10] →

Auto-generated CPSR Part A draft with source citations
CAS Number
103-36-6 [^1_10]
View industrial chemical safety profile →
Function
Flavouring and nutrient; Fragrance; No specific technical function; UV stabilizer
Safety Rating
MODERATE

Regulatory Status

EU EU Status restricted
US US Status permitted
US Notes Permitted — no 21 CFR restriction for cosmetic use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Cinnamate.

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Ethyl Cinnamate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Additional Ingredient Properties

2 property records from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "balsam-of-peru-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS/1459/11"}
fragrance_ifra
{"cas_number": "103-36-6", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.11", "ifra_max_use_level_category_4_pct": "1.8", "ifra_max_use_level_category_7_pct": "0.26", "ifra_max_use_level_category_11_pct": "0.052", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…

Expert Verdict

Expert safety assessment and concern-level summary for Ethyl Cinnamate.

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Ethyl Cinnamate by CAS number or substance name.

Studies
8
Lowest NOAEL
80 mg/kg bw/day
Highest NOAEL
800 mg/kg bw/day
COSMOS_DB ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip

Frequently Asked Questions

Is Ethyl Cinnamate safe in cosmetics?

Ethyl Cinnamate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.

Is Ethyl Cinnamate allowed in the EU?

Ethyl Cinnamate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Cinnamate do in cosmetics?

Ethyl Cinnamate functions as: Flavouring and nutrient; Fragrance; No specific technical function; UV stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 103-36-6 [^1_10].

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