Is Ethoxyethanol Acetate safe in cosmetics?
Ethoxyethanol Acetate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: prohibited.
Ethoxyethanol Acetate
Also known as: Ethylene glycol monoethyl ether acetate, 2-Ethoxyethanol, Acetate, Ektasolve EE acetate solvent, Ethoxyethyl acetate, 2-Ethoxyethylacetate (+15 more)
INCI: ETHOXYETHANOL ACETATE (2-ETHOXYETHANOL ACETATE)
Ethoxyethanol Acetate (CAS 111-15-9) is a cosmetic cosmetic ingredient functioning as Solvent, viscosity decreasing agent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-15-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethoxyethanol Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H332, H360FD, H320, H336, H360).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, viscosity decreasing agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-ethoxyethyl acetate
InChIKey
SVONRAPFKPVNKG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not specifically banned by FDA but classified as a reproductive toxicant. Listed on California Proposition 65. Most US manufacturers avoid it voluntarily due to toxicity classification.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethoxyethanol Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is mildly irritating to the eyes. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood. This may result in lesions of blood cells, anaemia and kidney impairment. May cause toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHealth HazardHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *
Hazard Statements
- H226 Flammable liquid and vapour
- H360FD
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Substance of Very High Concern (SVHC)
Included: 20-Jun-2011
Toxic for reproduction (Article 57c)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: 673
BRIN Brazil/India Cosmetics
Brazil: Prohibited
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0364
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Ethylene glycol monoethyl ether acetate (EGEEA) ...is somewhat irritating to the eyes, is not appreciably irritating to the skin... . | May be harmful if inhaled or absorbed through the skin, may cause reproductive effects; avoid breathing vapor ...
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
ETHOXYETHYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Fragrance
Solvent
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethoxyethanol Acetate.
Regulatory Flags
prop65
Known Synonyms
Ethylene glycol monoethyl ether acetate
2-Ethoxyethanol, Acetate
Ektasolve EE acetate solvent
Ethoxyethyl acetate
2-Ethoxyethylacetate
Ethylglycol acetate
Glycol ether EE acetate
Oxytol acetate
2-Aethoxy-aethylacetat
2-Ethoxy-ethylacetaat
2-Ethoxyethyle, acetate de
2-Ethoxyethylester kyseliny octove
2-Etossietil-acetato
Acetate de cellosolve
Acetate de l'ether monoethylique de l'ethylene-glycol
Acetate d'ethylglycol
Acetato di cellosolve
Aethylenglykolaetheracetat
Ethyl cellosolve acetaat
Ethylglykolacetat
Chemical Function
Solvent
Fragrance
Film former
Regulatory Lists
Cons electronics mech appliances and machinery; Europe
consumer_product
CEDI
Indirect additives food contact (10/2018)
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1427293
Frequently Asked Questions
Is Ethoxyethanol Acetate allowed in the EU?
Ethoxyethanol Acetate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethoxyethanol Acetate do in cosmetics?
Ethoxyethanol Acetate functions as: Solvent, viscosity decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 111-15-9.
Is Ethoxyethanol Acetate used outside cosmetics?
Ethoxyethanol Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethoxyethanol Acetate have different safety status in cosmetics vs industrial chemicals?
Ethoxyethanol Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H332, H360FD, H320, H336, H360).
Compliance Tools
Check Ethoxyethanol Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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