What is the NOAEL for 2-(2-Ethoxyethoxy)ethyl acetate?
2-(2-Ethoxyethoxy)ethyl acetate has 16 NOAEL studies in the database. The lowest reported value is 3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-(2-Ethoxyethoxy)ethyl acetate
Also known as: Ethanol, 2-(2-ethoxyethoxy)-, acetate, Diethylene glycol monoethyl ether acetate, Ethanol, 2-(2-ethoxyethoxy)-, 1-acetate, Acetic acid 2-(2-ethoxyethoxy)ethyl ester, BRN 1764643 (+9 more)
CAS 112-15-2
2-(2-Ethoxyethoxy)ethyl acetate (CAS 112-15-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
2-(2-Ethoxyethoxy)ethyl acetate
CAS Number
112-15-2
DTXSID
DTXSID6026905
Molecular Formula
C8H16O4
InChI Key
FPZWZCWUIYYYBU-UHFFFAOYSA-N
Monoisotopic Mass
176.104859
Synonyms
Ethanol, 2-(2-ethoxyethoxy)-, acetateDiethylene glycol monoethyl ether acetateEthanol, 2-(2-ethoxyethoxy)-, 1-acetateAcetic acid 2-(2-ethoxyethoxy)ethyl esterBRN 1764643Carbitol acetateDiethylene glycol ethyl ether acetateDiglycol monoethyl ether acetateEINECS 203-940-1Ektasolve de acetateGlycol ether de acetateNSC 8702
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
SolventFilm former
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =10.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| W5EIM81UBX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W5EIM81UBX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W5EIM81UBX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W5EIM81UBX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =480 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =72070.7 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| <250 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =520 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =167 | mg/kg bw/day | NOAEL | oral | Pig | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/m3 | NOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-ethoxyethoxy)ethyl acetate | 203-940-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3185106
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2-(2-Ethoxyethoxy)ethyl acetate?
2-(2-Ethoxyethoxy)ethyl acetate appears on 2 regulatory/inventory lists including artificial_sweat; detected; emissions; Europe; Toys and children's products, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 2-(2-Ethoxyethoxy)ethyl acetate used in cosmetics?
Yes, 2-(2-Ethoxyethoxy)ethyl acetate is also indexed as a cosmetic ingredient under the name ETHOXYDIGLYCOL ACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-(2-Ethoxyethoxy)ethyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-(2-Ethoxyethoxy)ethyl acetate used outside industrial chemicals?
2-(2-Ethoxyethoxy)ethyl acetate also appears in cosmetics, pharmaceutical databases.