Is EGF safe in cosmetics?
EGF has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
EGF
INCI: SH-OLIGOPEPTIDE-1
EGF (CAS 62253-63-8) is a cosmetic active ingredient functioning as Cell-communicating polypeptide (~6.2 kDa); binds EGFR driving keratinocyte and. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 62253-63-8 →
Auto-generated CPSR Part A draft with source citations
Function
Cell-communicating polypeptide (~6.2 kDa); binds EGFR driving keratinocyte and fibroblast proliferation; attenuates pro-inflammatory cytokines IL-1, IL-8, and TNF-α in keratinocytes; wound re-epithelialization support; anti-aging active
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA distinguishes cosmetic vs drug based on intended use claims. Purely aesthetic claims (hydration, appearance) are permissible. Claims such as accelerates wound healing or promotes cell regeneration may trigger drug classification requiring CDER approval under 21 CFR. No GRASE classification (not a sunscreen active). No specific restrictions in 21 CFR for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for EGF.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
amino_acid
{"cas_number": "62031-54-3", "ingredient_class": "oligopeptide", "source_origin": "recombinant", "molecular_weight_range_Da": "6000", "amino_acid_composition_key": "EGF_mimic", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "dermis…
peptide
{"cas_number": "62253-63-8", "trade_name": "EGF / Epidermal Growth Factor", "peptide_sequence_amino_acids": "Recombinant 53-amino acid protein", "peptide_length_residues": "53", "molecular_weight_daltons": "6045.0", "peptide_class": "signal", "mechanism_of_action": "Binds EGF receptor, stimulates keratinocyte proliferation and migration", "target_protein_or_receptor": "EGFR (ErbB1)", "biomimetic_o…
Expert Verdict
Expert safety assessment and concern-level summary for EGF.
Regulatory Flags
no-sccs-opinion
china-banned-variant
drug-cosmetic-boundary
claims-sensitive
peptide-stability-required
limited-dermal-absorption
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Frequently Asked Questions
Is EGF allowed in the EU?
EGF EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does EGF do in cosmetics?
EGF functions as: Cell-communicating polypeptide (~6.2 kDa); binds EGFR driving keratinocyte and fibroblast proliferation; attenuates pro-inflammatory cytokines IL-1, IL-8, and TNF-α in keratinocytes; wound re-epithelialization support; anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 62253-63-8.
Compliance Tools
Check EGF compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
Excellent
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
Excellent
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
Excellent
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
Excellent
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
Excellent
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
Excellent
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Potato SH-Oligopeptide-1
Moderate
Chemical family
Skin conditioning, skin protecting, w...
Rh-Oligopeptide-1
Moderate
Chemical family
Skin conditioning (recombinant human ...
SR-OLIGOPEPTIDE-1
Good
Chemical family
Skin Protecting
Is EGF in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for EGF in your formulation.