NOAEL Studies UV Filter / Sunscreen

EGCG (Epigallocatechin Gallate) NOAEL Studies

INCI: EGCG

CAS: 989-51-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 135 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=594; Record_ID=adme_parameters_794; Data_Type=Measured; DTXSID=DTXSID1029889; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=135.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029889; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1029889
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Dog oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9de4b0a7c65d1ce9fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8734/7/6/2?documentUUID=192fdef9-bdd1-47f4-8f13-61ddda4e26c1; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844431_15844432:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d2fcd4388ff96e94da2e67a628fa57a
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =60 mg/org Rat oral short-term; 28 days short-term LONG_REF=Pestic. Biochem. Physiol.91(2): 81-89 Elhalwagy,M.E.A., N.S. Darwish, and E.M. Zaher Prophylactic Effect of Green Tea Polyphenols Against Liver and Kidney Injury Induced by Fenitrothion Insecticide 2008; TITLE=Prophylactic Effect of Green Tea Polyphenols Against Liver and Kidney Injury Induced by Fenitrothion Insecticide; AUTHOR=Elhalwagy,M.E.A., N.S. Darwish, and E.M. Zaher; DOI=10.1016/j.pestbp.2008.01.006; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=105129; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Biochemistry: Albumin|Biochemistry: Glutathione (reduced glutathione)|Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595739_15598324:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aead435d2486dbaa6506b88b1e724151
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier BQM438CTEL UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H18O11","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BQM438CTEL"}
openFDA substances FDA UNII substance identifier BQM438CTEL UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H18O11","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BQM438CTEL"}
openFDA substances FDA UNII substance identifier BQM438CTEL UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H18O11","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BQM438CTEL"}
openFDA substances FDA UNII substance identifier BQM438CTEL UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H18O11","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BQM438CTEL"}