NOAEL Studies
Cosmetic Ingredient
DM HYDANTOIN NOAEL Studies
CAS: 77-71-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_dart 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 500 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=79714; Record_ID=dart_20; Data_Type=In Vivo; DTXSID=DTXSID5021754; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1883702;CUI;Supernumerary; Reference=ToxRefDB v2 , ID = 187; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021754 |
| NTP_ICE_dart | LOEL | 1000 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=79715; Record_ID=dart_28; Data_Type=In Vivo; DTXSID=DTXSID5021754; Assay=DART, In life observation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 187; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021754 |
| NTP_ICE_dart | LOEL | 1000 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=79716; Record_ID=dart_30; Data_Type=In Vivo; DTXSID=DTXSID5021754; Assay=DART, In life observation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 187; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021754 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4250; RecordID=ARPathway2016_1554; DatasetName=ARPathway2016; DTXSID=DTXSID5021754; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021754 |
ToxRefDB_ToxRefDB_v3_pod.csv 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 19 GD | DEV | study_id=190; toxval_study_source_id=studyid190_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-defecation|in life observation-mortality-mortality|in life observation-clinical signs-urination; dose_level=1; study_year=1987; study_citation=Sabol, E. J. RabbIt teratogenicity study, 5,5-Dimethylhydantoln, 91%, (Unpublished Project No. 3866-85 by Stlllmeadow, Inc., Biological Testing Laboratory,Houston, TX, for Applied Biochemists, Inc., Mequon, WI: July 30,1986) Accession # 265457; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =100 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 24 month | CHR | study_id=197; toxval_study_source_id=studyid197_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|clinical chemistry-glucose-glucose|in life observation-clinical signs-lethargy|in life observation-clinical signs-urogenital staining|pathology microscopic-eye-corneal crystals|organ weight-brain-absolute|pathology gross-mammary gland-cyst|pathology microscopic-lung-mineralization|in life observation-clinical signs-[other]|pathology microscopic-testes-degeneration|pathology gross-pituitary gland-enlarged|in life observation-mortality-mortality|organ weight-kidney-relative to brain weight|in life observation-clinical signs-head tilt|pathology gross-pituitary gland-discolored|pathology microscopic-lymph node-dilatation|pathology microscopic-pituitary gland-adenoma|pathology microscopic-kidney-dilatation|urinalysis-volume-volume; dose_level=1; study_year=1996; study_citation=Naas, D. (1996) Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337. Unpublished Study Prepared By Wil Research Labs, Inc. 4385 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =120 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=192; toxval_study_source_id=studyid192_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-feces, discoloration|in life observation-clinical signs-fur (altered appearance)|organ weight-adrenal gland-relative to brain weight|organ weight-adrenal gland-absolute|organ weight-adrenal gland-relative to body weight|pathology microscopic-adrenal gland-hypertrophy; dose_level=1; study_year=1995; study_citation=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =321.1 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 18 month | CHR | study_id=194; toxval_study_source_id=studyid194_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1996; study_citation=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >390 | mg/kg bw/day | rat | dermal | 0 day to 90 day | SUB | study_id=4343; toxval_study_source_id=studyid4343_Adult_F0_F_NA; dose_level=3; study_year=1994; study_citation=Chun, J. and Loughran, K. (1994) Ninety-Day Dermal Toxicity Study with 5,5-Dimethylhydantoin (DMH) in CD,. Rats. Lonza Inc., 17-17 Route 208, Fair Lawn, NJ 07410, study no. 92N1016.; dsstox_substance_id=DTXSID5021754; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =414 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=192; toxval_study_source_id=studyid192_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-feces, discoloration; dose_level=2; study_year=1995; study_citation=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >1000 | mg/kg bw/day | dog (beagle) | oral | 0 day to 13 week | SUB | study_id=185; toxval_study_source_id=studyid185_Adult_F0_F_NA; dose_level=3; study_year=1992; study_citation=Naas, D. (1992) 13-Week Oral (Capsule) Study In Dogs With DMH: Lab Project Number: Wil-12244. Unpublished Study Prepared By WIL Research Laboratories Inc. 748 P.; dsstox_substance_id=DTXSID5021754; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >1008.5 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 18 month | CHR | study_id=194; toxval_study_source_id=studyid194_Adult_F0_F_NA; dose_level=3; study_year=1996; study_citation=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1019 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 day to 90 day | SUB | study_id=183; toxval_study_source_id=studyid183_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-liver-relative to body weight|organ weight-liver-absolute; dose_level=3; study_year=1991; study_citation=Federici, T. (1991) 90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070. Unpublished study prepared by Lonza, Inc. 275 p.; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; vehicle=reverse osmosis water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1050 | mg/kg bw/day | rat (sprague-dawley; Sprague-Dawley) | oral | 0 day to 90 day | SUB | study_id=184; toxval_study_source_id=studyid184_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-exophthalamus|in life observation-body weight-body weight gain|in life observation-clinical signs-lacrimation or red-colored tears; dose_level=3; study_year=1986; study_citation=Galloway,C.C. and Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #: 265457, Sept. 5,1986; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =1506 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=192; toxval_study_source_id=studyid192_Adult_F0_M_systemic; toxval_effect_list=organ weight-adrenal gland-relative to brain weight|organ weight-adrenal gland-absolute|organ weight-adrenal gland-relative to body weight|pathology microscopic-adrenal gland-hypertrophy; dose_level=3; study_year=1995; study_citation=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 19 GD | DEV | study_id=190; toxval_study_source_id=studyid190_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-urination|in life observation-mortality-mortality|in life observation-clinical signs-defecation; dose_level=0; study_year=1987; study_citation=Sabol, E. J. RabbIt teratogenicity study, 5,5-Dimethylhydantoln, 91%, (Unpublished Project No. 3866-85 by Stlllmeadow, Inc., Biological Testing Laboratory,Houston, TX, for Applied Biochemists, Inc., Mequon, WI: July 30,1986) Accession # 265457; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =100 | mg/kg bw/day | rat (sprague-dawley; Sprague-Dawley) | oral | 0 day to 90 day | SUB | study_id=184; toxval_study_source_id=studyid184_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lacrimation or red-colored tears|in life observation-body weight-body weight gain|in life observation-clinical signs-exophthalamus; dose_level=2; study_year=1986; study_citation=Galloway,C.C. and Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #: 265457, Sept. 5,1986; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =100.6 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 18 month | CHR | study_id=194; toxval_study_source_id=studyid194_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1996; study_citation=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =121 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=192; toxval_study_source_id=studyid192_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-feces, discoloration; dose_level=1; study_year=1995; study_citation=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =300 | mg/kg bw/day | rat | oral | 6 GD to 15 GD | DEV | study_id=189; toxval_study_source_id=studyid189_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1992; study_citation=Driscoll, C.; Neeper-Bradley, T. (1992) Developmental Toxicity Evaluation Of 5,5-Dimethylhydantoin (Dmh) Administered By Gavage To Cd Rats: Lab Project Number: 91N0048. Unpublished Study Prepared By Union Carbide Chemicals Inc, Brrc. 286 P.; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =303 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 day to 90 day | SUB | study_id=183; toxval_study_source_id=studyid183_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-absolute|in life observation-body weight-body weight|organ weight-liver-absolute; dose_level=2; study_year=1991; study_citation=Federici, T. (1991) 90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070. Unpublished study prepared by Lonza, Inc. 275 p.; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; vehicle=reverse osmosis water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =320 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 24 month | CHR | study_id=197; toxval_study_source_id=studyid197_Adult_F0_F_systemic; toxval_effect_list=pathology gross-pituitary gland-enlarged|organ weight-kidney-relative to brain weight|pathology microscopic-eye-corneal crystals|pathology gross-mammary gland-cyst|pathology microscopic-lymph node-dilatation|clinical chemistry-glucose-glucose|in life observation-clinical signs-[other]|organ weight-brain-absolute|pathology microscopic-pituitary gland-adenoma|in life observation-mortality-mortality|in life observation-clinical signs-head tilt|pathology gross-pituitary gland-discolored|in life observation-clinical signs-urogenital staining|urinalysis-specific gravity/osmolality-specific gravity/osmolality|urinalysis-volume-volume; dose_level=2; study_year=1996; study_citation=Naas, D. (1996) Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337. Unpublished Study Prepared By Wil Research Labs, Inc. 4385 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =500 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=187; toxval_study_source_id=studyid187_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=1992; study_citation=Nemec, M. (1992) A Developmental Toxicity Study Of Dimethylhydantoin In Rabbits: Final Report (Report Text And Data): Lab Project Number: WIL-12174. Unpublished Study Prepared By WIL Research Labs Inc. 61 P.; dsstox_substance_id=DTXSID5021754; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =342 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=192; toxval_study_source_id=studyid192_Adult_F0_M_systemic; toxval_effect_list=organ weight-adrenal gland-relative to body weight|in life observation-clinical signs-fur (altered appearance)|organ weight-adrenal gland-absolute|organ weight-adrenal gland-relative to brain weight|in life observation-clinical signs-feces, discoloration|pathology microscopic-adrenal gland-hypertrophy; dose_level=2; study_year=1995; study_citation=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; dsstox_substance_id=DTXSID5021754; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =23.4 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cbc05; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/6/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15847980:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_93b93ed02ff73266ef4565c606aa7222 |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cbbfb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/6/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15848742:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f6c6069e8f0557c126d04c14c4e2b631 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/3?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15823391:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9932bf3d55b986ee4cd7056ac9954c25 |
| ToxValDB_ECHA_IUCLID | NOEL | =300 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b477d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/8?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15820059:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_57e0126f2c3c2163d8662b816889dd9d |
| ToxValDB_ECHA_IUCLID | NOEL | =379 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15860662:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_61e39a2200f543772674748c4fe306f7 |
| ToxValDB_ECHA_IUCLID | NOEL | =390 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61dd6e4b096bca87775a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/6/4?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15826329:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36a6ddab85f978007724a9b034311d22 |
| ToxValDB_ECHA_IUCLID | NOEL | =475 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15861370:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4bb0d3e8aa63a63a300a3e64b5aede00 |
| ToxValDB_ECHA_IUCLID | NOEL | >=1000 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4780; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/8?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15820070:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_71286aa9b7372fcaf9b504bbd3155284 |
| ToxValDB_ECHA_IUCLID | NOEL | =1395 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15860879:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2a550e618fd3c12d3cdfe170f1cf979 |
| ToxValDB_ECHA_IUCLID | NOEL | =1774 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15861221:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_553f6ccab5a020b79315a4864645d3ca |
| ToxValDB_ECHA_IUCLID | NOEL | =6000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30084/7/9/2?documentUUID=df39d935-ecd7-47e7-a400-961497661acb; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID:15860055:M:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6125844514e8f00bdbc2fb2ed58464c8 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =60 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631410:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_691c59d9c58a1c08a9e1422a3c93426e |
ToxValDB_HPVIS 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =5000 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Mayhew, D. A. 1982. 90-day oral gavage study in rats dosed with dimethylhydantoin (DMH). Project number WIL-81165. WIL Research Laboratories, Inc., Cincinnati, OH, US.; TITLE=90-day oral gavage study in rats dosed with dimethylhydantoin (DMH); AUTHOR=Mayhew, D. A; QUALITY=1; EXTERNAL_SOURCE_ID=63865; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT_CATEGORY=-|multiple; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639726_15640094:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1daf80e6e68a9791511c916b7a33ad94 |
| ToxValDB_HPVIS | LOAEL | =9850 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Naas, D. J. 1991. 90-day dietary study in mice with DMH. Project number WIL-12186. WIL Research Laboratories, Inc., Ashland, OH, US.; TITLE=90-day dietary study in mice with DMH. Project number WIL-12186; AUTHOR=Naas, D. J; QUALITY=1; EXTERNAL_SOURCE_ID=62278; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15639284:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dec6383440f4ebfb0cd9ee43602d69ab |
| ToxValDB_HPVIS | NOAEL | =100 | mg/kg bw/day | Rabbit | oral | short-term; 13 days | developmental | LONG_REF=Nemec, M. D. 1992. A developmental toxicity study of dimethylhydantoin in rabbits. Study number WIL-12174. WIL Research Laboratories, Inc., Ashland, OH, US.Nemec, M. D. 1989. A range-finding developmental toxicity study of dimethylhydantoin in rabbits. Study number WIL-12151. WIL Research Laboratories, Inc., Ashland, OH, US.; QUALITY=1; EXTERNAL_SOURCE_ID=57904; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15642292:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d0c3c20f6116d67a934134e14c0d01a |
| ToxValDB_HPVIS | NOAEL | =250 | mg/kg bw/day | Rat | oral | - | developmental | LONG_REF=Nemec, M. D. 1992. Two-generation reproduction study of dimethylhydantoin administered orally in rats. Study number WIL-12153. WIL Research Laboratories, Inc., Ashland, OH, US.; TITLE=Two-generation reproduction study of dimethylhydantoin administered orally in rats. Study number WIL-12153; AUTHOR=Nemec, MD; QUALITY=1; EXTERNAL_SOURCE_ID=65521; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS:15643264:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_967a458053e925db9098e4567af1e6ad |
| ToxValDB_HPVIS | NOAEL | =500 | mg/kg bw/day | Rabbit | oral | short-term; 13 days | reproduction developmental | LONG_REF=Nemec, M. D. 1992. A developmental toxicity study of dimethylhydantoin in rabbits. Study number WIL-12174. WIL Research Laboratories, Inc., Ashland, OH, US.Nemec, M. D. 1989. A range-finding developmental toxicity study of dimethylhydantoin in rabbits. Study number WIL-12151. WIL Research Laboratories, Inc., Ashland, OH, US.; QUALITY=1; EXTERNAL_SOURCE_ID=57903; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15642291:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cec9b9d1080215b151ab2d2c581c670e |
| ToxValDB_HPVIS | NOAEL | =2000 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Mayhew, D. A. 1982. 90-day oral gavage study in rats dosed with dimethylhydantoin (DMH). Project number WIL-81165. WIL Research Laboratories, Inc., Cincinnati, OH, US.; TITLE=90-day oral gavage study in rats dosed with dimethylhydantoin (DMH); AUTHOR=Mayhew, D. A; QUALITY=1; EXTERNAL_SOURCE_ID=61248; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639726_15640094:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e5440fe7483b18f0b8be1f1fb9fcbfc8 |
| ToxValDB_HPVIS | NOAEL | =20000 | ppm | Rat | oral | subchronic; 10 weeks | reproduction developmental | LONG_REF=Neeper-Bradley, T. L. and M. F. Kubena. 1994. Two-generation reproduction study in CD rats with 5,5-dimethylhydantoin administered in the diet. Project number 91N0094. Bushy Run Research Center, Union Carbide Corporation, Export, PA, US.; TITLE=Two-generation reproduction study in CD rats with 5,5-dimethylhydantoin administered in the diet. Project number 91N0094; AUTHOR=Neeper-Bradley, T. L. and M. F. Kubena; QUALITY=1; EXTERNAL_SOURCE_ID=65520; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS:15643263:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fc829326575e3b78f6704e0c7d9dd289 |
| ToxValDB_HPVIS | NOAEL | =50000 | ppm | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Naas, D. J. 1991. 28-day dietary study in mice with DMH. Study number WIL-12164. WIL Research Laboratories, Inc., Ashland, OH, US.; TITLE=28-day dietary study in mice with DMH. Study number WIL-12164; AUTHOR=Naas, D. J; QUALITY=1; EXTERNAL_SOURCE_ID=61247; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15639725:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d31b78c4d4d93a1db7e82bc6b0b3bb5 |
ToxValDB_ToxRefDB 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =1 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 14 days | reproduction developmental | LONG_REF=Sabol, E. J. RabbIt teratogenicity study, 5,5-Dimethylhydantoln, 91%, (Unpublished Project No. 3866-85 by Stlllmeadow, Inc., Biological Testing Laboratory,Houston, TX, for Applied Biochemists, Inc., Mequon, WI: July 30,1986) Accession # 265457; TITLE=RabbIt teratogenicity study, 5,5-Dimethylhydantoln, 91%; AUTHOR=Sabol, E. J; EXTERNAL_SOURCE_ID=190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-urination; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15678513_15678514:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acc0106afd79fc736792b77b955c43b3 |
| ToxValDB_ToxRefDB | LEL | =100 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Naas, D. (1996) Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337. Unpublished Study Prepared By Wil Research Labs, Inc. 4385 P.; TITLE=Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=197; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: clinical chemistry-glucose-glucose|systemic: in life observation-clinical signs-lethargy|systemic: in life observation-clinical signs-urogenital staining|systemic: organ weight-brain-absolute|systemic: pathology gross-pituitary gland-enlarged|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-dilatation|systemic: organ weight-kidney-relative to brain weight|systemic: pathology gross-mammary gland-cyst|systemic: in life observation-clinical signs-head tilt|systemic: pathology microscopic-lung-mineralization|systemic: urinalysis-volume-volume|systemic: pathology gross-pituitary gland-discolored|systemic: pathology microscopic-eye-corneal crystals|systemic: pathology microscopic-lymph node-dilatation|systemic: in life observation-clinical signs-[other]|systemic: pathology microscopic-pituitary gland-adenoma|systemic: pathology microscopic-testes-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15678576_15678577_15678578:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce2cd7daaa7575455639f7e7658ed0c4 |
| ToxValDB_ToxRefDB | LEL | =120 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; TITLE=Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=192; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-feces, discoloration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: organ weight-adrenal gland-relative to brain weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology microscopic-adrenal gland-hypertrophy|systemic: organ weight-adrenal gland-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15678537_15678538_15678539:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da6d27b8238ecfe612546667e1fb3cca |
| ToxValDB_ToxRefDB | LEL | =321.1 | mg/kg bw/day | Mouse | oral | chronic; 18 months | chronic | LONG_REF=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; TITLE=18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=194; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15678552_15678553_15678554_15678555:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f297eee88d62f6fec7e39b62458773db |
| ToxValDB_ToxRefDB | LEL | =414 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; TITLE=Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=192; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-feces, discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15678535_15678536:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db28e76d9a91c3ea08ade29fa960b117 |
| ToxValDB_ToxRefDB | LEL | =500 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Nemec, M. (1992) A Developmental Toxicity Study Of Dimethylhydantoin In Rabbits: Final Report (Report Text And Data): Lab Project Number: WIL-12174. Unpublished Study Prepared By WIL Research Labs Inc. 61 P.; TITLE=A Developmental Toxicity Study Of Dimethylhydantoin In Rabbits: Final Report (Report Text And Data): Lab Project Number: WIL-12174; AUTHOR=Nemec, M; EXTERNAL_SOURCE_ID=187; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-bone-supernumerary|developmental: developmental malformation-heart-[other]|developmental: developmental malformation-paw / digit-adactyly|developmental: developmental malformation-bone-short supernumerary; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15678501_15678502_15678503_15678504:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28d9ce017892a13fc2b46f0294b00b66 |
| ToxValDB_ToxRefDB | LEL | >1000 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | LONG_REF=Naas, D. (1992) 13-Week Oral (Capsule) Study In Dogs With DMH: Lab Project Number: Wil-12244. Unpublished Study Prepared By WIL Research Laboratories Inc. 748 P.; TITLE=13-Week Oral (Capsule) Study In Dogs With DMH: Lab Project Number: Wil-12244; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=185; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ToxRefDB_dup_-_15678489_15678490_15678491_15678492:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_271d8c44da1f60a40f53792a0ac229f5 |
| ToxValDB_ToxRefDB | LEL | >1008.5 | mg/kg bw/day | Mouse | oral | chronic; 18 months | chronic | LONG_REF=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; TITLE=18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=194; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ToxRefDB_dup_-_15678548_15678549_15678550_15678551:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4199f85e360de35fa9bc9417bc98c550 |
| ToxValDB_ToxRefDB | LEL | =1019 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Federici, T. (1991) 90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070. Unpublished study prepared by Lonza, Inc. 275 p.; TITLE=90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070; AUTHOR=Federici, T; EXTERNAL_SOURCE_ID=183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15678479_15678480:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd11a3c19356d1bf824c26bc06a58363 |
| ToxValDB_ToxRefDB | LEL | =1050 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Galloway,C.C. & Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #: 265457, Sept. 5,1986; TITLE=Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin; AUTHOR=Galloway,C.C. & Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #; EXTERNAL_SOURCE_ID=184; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-lacrimation or red-colored tears|systemic: in life observation-clinical signs-exophthalamus; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15678485_15678486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58dd59b93c0946ef0f8ee8dec8039202 |
| ToxValDB_ToxRefDB | LOAEL | =1506 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; TITLE=Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=192; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-adrenal gland-relative to brain weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology microscopic-adrenal gland-hypertrophy|systemic: organ weight-adrenal gland-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15678537_15678538_15678539:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e8ed7032ffae2c0aa92444bd501e41c |
| ToxValDB_ToxRefDB | NEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Galloway,C.C. & Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #: 265457, Sept. 5,1986; TITLE=Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin; AUTHOR=Galloway,C.C. & Maedgen,J.L., Subchronic toxicity oral gavage study in Rats.5,5-Dimethylhydantoin: Study #:3868-85: Applied Biochemists,Inc., WI.Accession #; EXTERNAL_SOURCE_ID=184; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-exophthalamus|systemic: in life observation-clinical signs-lacrimation or red-colored tears|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15678485_15678486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5b11aab44d6b9e5c61e6548a330f67e |
| ToxValDB_ToxRefDB | NEL | =100.6 | mg/kg bw/day | Mouse | oral | chronic; 18 months | chronic | LONG_REF=Naas, D. (1996) 18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196. Unpublished Study Prepared By Wil Research Labs, Inc. 2851 P.; TITLE=18-Month Dietary Oncogenicity Study In Mice With Dmh: (Amended) Final Report: Lab Project Number: Wil-12257: Pjb-96-196; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=194; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15678552_15678553_15678554_15678555:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b715a90dd80a411b0974086dd8198fd6 |
| ToxValDB_ToxRefDB | NEL | =121 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; TITLE=Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=192; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-feces, discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15678535_15678536:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c5dffbb87f3543e9e45295e8da65d93 |
| ToxValDB_ToxRefDB | NEL | =300 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Driscoll, C.; Neeper-Bradley, T. (1992) Developmental Toxicity Evaluation Of 5,5-Dimethylhydantoin (Dmh) Administered By Gavage To Cd Rats: Lab Project Number: 91N0048. Unpublished Study Prepared By Union Carbide Chemicals Inc, Brrc. 286 P.; TITLE=Developmental Toxicity Evaluation Of 5,5-Dimethylhydantoin (Dmh) Administered By Gavage To Cd Rats: Lab Project Number: 91N0048; AUTHOR=Driscoll, C.; Neeper-Bradley, T; EXTERNAL_SOURCE_ID=189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15678505_15678506_15678507_15678508:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1544b5e2cf165c125f57b451a0b34731 |
| ToxValDB_ToxRefDB | NEL | =303 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Federici, T. (1991) 90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070. Unpublished study prepared by Lonza, Inc. 275 p.; TITLE=90-Day Subchronic Oral Toxicity Study in Rats with Dimethylhydantoin: Lab Project Number: 169070; AUTHOR=Federici, T; EXTERNAL_SOURCE_ID=183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: organ weight-kidney-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15678479_15678480:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99be000655ad5d305e2f49e621c93937 |
| ToxValDB_ToxRefDB | NEL | =320 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Naas, D. (1996) Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337. Unpublished Study Prepared By Wil Research Labs, Inc. 4385 P.; TITLE=Combined 24-Month Toxicity/Oncogenicity Study In Rats With (Inert Ingredient): Final Report: Lab Project Number: Wil-12258: Pjb-96-337; AUTHOR=Naas, D; EXTERNAL_SOURCE_ID=197; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-head tilt|systemic: in life observation-clinical signs-[other]|systemic: organ weight-brain-absolute|systemic: pathology gross-pituitary gland-enlarged|systemic: pathology gross-pituitary gland-discolored|systemic: organ weight-kidney-relative to brain weight|systemic: in life observation-clinical signs-urogenital staining|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-pituitary gland-adenoma|systemic: urinalysis-volume-volume|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-eye-corneal crystals|systemic: clinical chemistry-glucose-glucose|systemic: pathology gross-mammary gland-cyst|systemic: pathology microscopic-lymph node-dilatation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15678572_15678573_15678574_15678575:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7d53c0f3f954351c719234c4ff7870e |
| ToxValDB_ToxRefDB | NOAEL | =342 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Goldenthal, E. (1995) Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004. Unpublished Study Prepared By International Research And Development Corp. 355 P.; TITLE=Evaluation Of Dimethylhydantoin (DMH) In A One-Year Chronic Dietary Toxicity Study In Dogs: Lab Project Number: 647-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=192; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-hypertrophy|systemic: organ weight-adrenal gland-relative to body weight|systemic: organ weight-adrenal gland-relative to brain weight|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: organ weight-adrenal gland-absolute|systemic: in life observation-clinical signs-feces, discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15678537_15678538_15678539:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be66d047e397b649483ce96f73da5f55 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 34032MQ9RO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"34032MQ9RO"} |
| openFDA substances | FDA UNII substance identifier | 34032MQ9RO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"34032MQ9RO"} |
| openFDA substances | FDA UNII substance identifier | 34032MQ9RO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"34032MQ9RO"} |
| openFDA substances | FDA UNII substance identifier | 34032MQ9RO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"34032MQ9RO"} |