Is Disodium Isodecyl Sulfosuccinate safe in cosmetics?
Disodium Isodecyl Sulfosuccinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Disodium Isodecyl Sulfosuccinate
Also known as: Butanedioic acid, sulfo-, 4-isodecyl ester, disodium salt, EINECS 253-452-8
INCI: DISODIUM ISODECYL SULFOSUCCINATE
Disodium Isodecyl Sulfosuccinate (CAS 37294-49-8) is a cosmetic cosmetic ingredient functioning as Surfactant, cleansing agent, foaming agent, skin conditioning. Reported NOAEL =300 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 37294-49-8 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant, cleansing agent, foaming agent, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;8-methylnonan-1-ol;2-sulfobutanedioic acid
InChIKey
YBNSWAFWAWIDJZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted. CIR reviewed alkyl sulfosuccinate salts as safe; also FDA-approved indirect food additive.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Isodecyl Sulfosuccinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Disodium Isodecyl Sulfosuccinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Foamant
Softener and conditioner
Solubility enhancer
Surfactant (surface active agent)
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Isodecyl Sulfosuccinate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Disodium Isodecyl Sulfosuccinate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Butanedioic acid, sulfo-, 4-isodecyl ester, disodium salt
EINECS 253-452-8
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Softener and conditioner
Cleaning agent
Foamant
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Disodium Isodecyl Sulfosuccinate allowed in the EU?
Disodium Isodecyl Sulfosuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Isodecyl Sulfosuccinate do in cosmetics?
Disodium Isodecyl Sulfosuccinate functions as: Surfactant, cleansing agent, foaming agent, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 37294-49-8.
What is the NOAEL for Disodium Isodecyl Sulfosuccinate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Isodecyl Sulfosuccinate is =300 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Disodium Isodecyl Sulfosuccinate used outside cosmetics?
Disodium Isodecyl Sulfosuccinate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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