NOAEL Studies Cosmetic Ingredient

Dipalmitoyl Hydroxyproline NOAEL Studies

INCI: DIPALMITOYL HYDROXYPROLINE

CAS: 41672-81-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6412; row=11204; data_type=In Vivo; mixture=Chemical; chemical_name=L-Proline, 1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxy]-, (4R)-; preferred_name=L-Proline, 1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxy]-, (4R)-; dtxsid=DTXSID60885734; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID60885734; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral subchronic; 54 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae37e4b0a7c65d1c82b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20945/7/6/2?documentUUID=57ed5713-ea6f-4b6b-b37b-46608153cab8; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15842569:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e251d7f42e71d34edcce33876e10337c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17.63 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633949:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_52e34cc397eb182006c67fbdfb4ce91d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E6AHA53N1H UNII - - - chemical {"approval_status":null,"molecular_formula":"C37H69NO5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6AHA53N1H"}
openFDA substances FDA UNII substance identifier E6AHA53N1H UNII - - - chemical {"approval_status":null,"molecular_formula":"C37H69NO5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6AHA53N1H"}
openFDA substances FDA UNII substance identifier E6AHA53N1H UNII - - - chemical {"approval_status":null,"molecular_formula":"C37H69NO5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6AHA53N1H"}
openFDA substances FDA UNII substance identifier E6AHA53N1H UNII - - - chemical {"approval_status":null,"molecular_formula":"C37H69NO5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6AHA53N1H"}