Is Dipalmitoyl Hydroxyproline safe in cosmetics?
Dipalmitoyl Hydroxyproline has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dipalmitoyl Hydroxyproline
Also known as: HYDROXYPROLINE
INCI: DIPALMITOYL HYDROXYPROLINE
Dipalmitoyl Hydroxyproline (CAS 41672-81-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Hair Conditioning, Antistatic. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 41672-81-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Hair Conditioning, Antistatic
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S,4R)-1-hexadecanoyl-4-hexadecanoyloxypyrrolidine-2-carboxylic acid
InChIKey
QZLXCFQVOCEKSX-NOCHOARKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Listed in FDA Global Substance Registration System (GSRS). No specific FDA restrictions; would require ingredient declaration under MoCRA product listing.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dipalmitoyl Hydroxyproline.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dipalmitoyl Hydroxyproline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dipalmitoyl Hydroxyproline across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Peptide derivative"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Amino acid derivative; safe", "source": "dermatology literature"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Dipalmitoyl Hydroxyproline.
Regulatory Flags
no-sccs-opinion
no-cir-individual-review
supplier-data-dependent
h319-raw-material
h412-raw-material
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dipalmitoyl Hydroxyproline by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
HYDROXYPROLINE
Chemical Function
Anti-static agent
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Dipalmitoyl Hydroxyproline allowed in the EU?
Dipalmitoyl Hydroxyproline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipalmitoyl Hydroxyproline do in cosmetics?
Dipalmitoyl Hydroxyproline functions as: Skin Conditioning, Hair Conditioning, Antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 41672-81-5.
What is the NOAEL for Dipalmitoyl Hydroxyproline?
The NOAEL (No Observed Adverse Effect Level) for Dipalmitoyl Hydroxyproline is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dipalmitoyl Hydroxyproline used outside cosmetics?
Dipalmitoyl Hydroxyproline also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dipalmitoyl Hydroxyproline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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