Is Dioctyl Maleate safe in cosmetics?
Dioctyl Maleate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dioctyl Maleate
Also known as: Bis(2-ethylhexyl) (2Z)-but-2-enedioate, 2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester, Bis(2-ethylhexyl)maleate, BRN 1729133, Di-(2-ethylhexyl)maleate (+5 more)
INCI: DIOCTYL MALEATE
Dioctyl Maleate (CAS 142-16-5) is a cosmetic cosmetic ingredient functioning as Emollient, Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 142-16-5 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
bis(2-ethylhexyl) (Z)-but-2-enedioate
InChIKey
ROPXFXOUUANXRR-YPKPFQOOSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions; parent maleic acid cleared as indirect food additive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dioctyl Maleate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dioctyl Maleate.
Regulatory Flags
reproductive-toxicity-flag-cat2
no-cir-review
no-sccs-opinion
no-dermal-absorption-data
no-sensitization-data
commission-studies-recommended
Known Synonyms
Bis(2-ethylhexyl) (2Z)-but-2-enedioate
2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester
Bis(2-ethylhexyl)maleate
BRN 1729133
Di-(2-ethylhexyl)maleate
"Dioctyl" maleate
EINECS 205-524-5
RC Comonomer DOM
Bis-(2-ethylhexyl)ester kyseliny maleinove
UNII-C2F7JHI12L
Chemical Function
Softener and conditioner
Plasticizer
Regulatory Lists
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1881816
Frequently Asked Questions
Is Dioctyl Maleate allowed in the EU?
Dioctyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dioctyl Maleate do in cosmetics?
Dioctyl Maleate functions as: Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 142-16-5.
Is Dioctyl Maleate used outside cosmetics?
Dioctyl Maleate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dioctyl Maleate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acacia Decurrens/Jojoba/Sunflower Seed Wax Polyglyceryl-3 Esters
Excellent
Same category
Skin conditioning emollient, texturizer
Acetic/Linoleic/Palmitic Triglyceride
Excellent
Same category
Skin conditioning (emollient)
Acetyl Ornithine
Excellent
Same category
Emollient
Acetyl Proline
Excellent
Same category
Emollient
Acetyl Triethylhexyl Citrate
Excellent
Same category
Emollient, Film Forming, Plasticiser
Acetyl Trihexyl Citrate
Excellent
Same category
Plasticiser, Skin Conditioning (Emoll...
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
2,4-Hexadienal
Moderate
Chemical family
Fragrance
Acetamide MEA
Moderate
Chemical family
Humectant; hair and skin conditioning...
Allyl Heptanoate
Good
Chemical family
Fragrance (perfuming agent)
Is Dioctyl Maleate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dioctyl Maleate in your formulation.