What is the NOAEL for Bis(2-ethylhexyl) maleate?
Bis(2-ethylhexyl) maleate has 7 NOAEL studies in the database. The lowest reported value is 7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Bis(2-ethylhexyl) maleate
Also known as: Bis(2-ethylhexyl) (2Z)-but-2-enedioate, 2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester, Bis(2-ethylhexyl)maleate, BRN 1729133, Di-(2-ethylhexyl)maleate (+5 more)
CAS 142-16-5
Bis(2-ethylhexyl) maleate (CAS 142-16-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Bis(2-ethylhexyl) maleate
CAS Number
142-16-5
DTXSID
DTXSID2027094
Molecular Formula
C20H36O4
InChI Key
ROPXFXOUUANXRR-YPKPFQOOSA-N
Monoisotopic Mass
340.26136
Synonyms
Bis(2-ethylhexyl) (2Z)-but-2-enedioate2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) esterBis(2-ethylhexyl)maleateBRN 1729133Di-(2-ethylhexyl)maleate"Dioctyl" maleateEINECS 205-524-5RC Comonomer DOMBis-(2-ethylhexyl)ester kyseliny maleinoveUNII-C2F7JHI12L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
Softener and conditionerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| C2F7JHI12L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C2F7JHI12L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C2F7JHI12L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C2F7JHI12L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| ~1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis(2-ethylhexyl) maleate | 205-524-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1881816
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Bis(2-ethylhexyl) maleate?
Bis(2-ethylhexyl) maleate appears on 2 regulatory/inventory lists including detected; Europe; Toys and children's products, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Bis(2-ethylhexyl) maleate used in cosmetics?
Yes, Bis(2-ethylhexyl) maleate is also indexed as a cosmetic ingredient under the name Dioctyl Maleate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bis(2-ethylhexyl) maleate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Bis(2-ethylhexyl) maleate used outside industrial chemicals?
Bis(2-ethylhexyl) maleate also appears in cosmetics, pharmaceutical databases.