Is Dilauryl Thiodipropionate safe in cosmetics?
Dilauryl Thiodipropionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dilauryl Thiodipropionate
Also known as: 4-03-00-00744, BRN 1808848, Dilauryl thiodipropionic acid, EINECS 204-614-1, 3,3'-Thiobispropionic acid, didodecyl ester (+3 more)
INCI: DILAURYL THIODIPROPIONATE
Dilauryl Thiodipropionate (CAS 123-28-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, Sequestering Agent, Fragrance. NOAEL 350 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 123-28-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Sequestering Agent, Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dodecyl 3-(3-dodecoxy-3-oxopropyl)sulfanylpropanoate
InChIKey
GHKOFFNLGXMVNJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as food substance under 21 CFR 182.3109 (total antioxidant content ≤0.02% of fat/oil content). CIR (2010 amended assessment) deemed safe for use in cosmetics formulated to be non-irritating.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dilauryl Thiodipropionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dilauryl Thiodipropionate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
An eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
DILAURYL THIODIPROPIONATE | 1973 | 0-3 mg/kg bw | Calculated as thiodipropionic acid | NMRS 53/TRS 539-JECFA 17/19 | FAS 5/NMRS 53A-JECFA 17/205
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Heat stabilizer
Plasticizer
Preservative
UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dilauryl Thiodipropionate.
Regulatory Flags
cir-safe
gras-fda
no-sccs-opinion
non-genotoxic
oil-soluble-only
non-irritating-as-formulated
ifra_fragrance
fda_food_additive
Known Synonyms
4-03-00-00744
BRN 1808848
Dilauryl thiodipropionic acid
EINECS 204-614-1
3,3'-Thiobispropionic acid, didodecyl ester
Thiodipropionic acid, dilauryl ester
Dilaurylester kyseliny beta',beta'-thiodipropionove
UNII-V51YH1B080
Chemical Function
Preservative
Antioxidant
Fragrance
Heat stabilizer
Plasticizer
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dilauryl Thiodipropionate allowed in the EU?
Dilauryl Thiodipropionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dilauryl Thiodipropionate do in cosmetics?
Dilauryl Thiodipropionate functions as: Antioxidant, Sequestering Agent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 123-28-4.
Is Dilauryl Thiodipropionate used outside cosmetics?
Dilauryl Thiodipropionate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dilauryl Thiodipropionate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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