Is Dihydrogen Phosphate safe in cosmetics?
Dihydrogen Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Dihydrogen Phosphate
Also known as: EINECS 237-066-7, Orthophosphorus acid, Phosphorus trihydroxide, Trihydroxyphosphine, UNII-35V6A8JW8E (+2 more)
INCI: DIHYDROGEN PHOSPHATE
Dihydrogen Phosphate (CAS 13598-36-2) is a cosmetic cosmetic ingredient functioning as Buffering, pH adjustment. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 13598-36-2 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering, pH adjustment
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
phosphonic acid
InChIKey
ABLZXFCXXLZCGV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Phosphate salts generally recognized as safe; widely used as pH buffer in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydrogen Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydrogen Phosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Corrosion inhibitor
Oxidizing agent
Processing aids not otherwise specified
Surfactant (surface active agent)
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Dihydrogen Phosphate.
Regulatory Flags
pH-adjuster
buffer
inorganic
CIR-reviewed
epa_safer_alternative
Known Synonyms
EINECS 237-066-7
Orthophosphorus acid
Phosphorus trihydroxide
Trihydroxyphosphine
UNII-35V6A8JW8E
H3PO3
Phosphonate
Chemical Function
Surfactant (surface active agent)
Oxidizing agent
Corrosion inhibitor
Processing aids not otherwise specified
Regulatory Lists
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PHOSPHONIC ACID
ChEMBL ID
CHEMBL1235291
Frequently Asked Questions
Is Dihydrogen Phosphate allowed in the EU?
Dihydrogen Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrogen Phosphate do in cosmetics?
Dihydrogen Phosphate functions as: Buffering, pH adjustment. It is classified as a cosmetic ingredient in our database. CAS number: 13598-36-2.
Is Dihydrogen Phosphate used outside cosmetics?
Dihydrogen Phosphate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydrogen Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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