What is the NOAEL for Phosphonic acid?
Phosphonic acid has 27 NOAEL studies in the database. The lowest reported value is 1 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phosphonic acid
Also known as: EINECS 237-066-7, Orthophosphorus acid, Phosphorus trihydroxide, Trihydroxyphosphine, UNII-35V6A8JW8E (+2 more)
CAS 13598-36-2
Phosphonic acid (CAS 13598-36-2) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Phosphonic acid is classified GHS Danger (H290, H302, H314, H318, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
27
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Phosphonic acid
CAS Number
13598-36-2
DTXSID
DTXSID2049715
Molecular Formula
H3O3P
InChI Key
ABLZXFCXXLZCGV-UHFFFAOYSA-N
Monoisotopic Mass
81.981981
Synonyms
EINECS 237-066-7Orthophosphorus acidPhosphorus trihydroxideTrihydroxyphosphineUNII-35V6A8JW8EH3PO3Phosphonate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Surfactant (surface active agent)Oxidizing agentCorrosion inhibitorProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 27 of 27 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =3.9 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =3.9 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.94 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 35V6A8JW8E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 35V6A8JW8E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 35V6A8JW8E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 35V6A8JW8E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_EFSA |
| =100 | mg/kg bw/day | NOAEL | - | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOAEL | - | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =224.47 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =224.47 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =224.47 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =284.7 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =284.7 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =284.7 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =390 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =390 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =390 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 27 of 27 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phosphonic acid | 237-066-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Minerals
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHOSPHONIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phosphonic acid?
Phosphonic acid appears on 1 regulatory/inventory list including SCIL (9/2019). Source: EPA CPDat.
Is Phosphonic acid used in cosmetics?
Yes, Phosphonic acid is also indexed as a cosmetic ingredient under the name Dihydrogen Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phosphonic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Phosphonic acid have different safety status in cosmetics vs industrial chemicals?
Phosphonic acid is classified GHS Danger (H290, H302, H314, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Is Phosphonic acid used outside industrial chemicals?
Phosphonic acid also appears in cosmetics, pharmaceutical, cannabis databases.