Is Dihydrocitronellyl Acetate safe in cosmetics?
Dihydrocitronellyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dihydrocitronellyl Acetate
Also known as: Tetrahydrogeranyl acetate, 1-Octanol, 3,7-dimethyl-, acetate, 1-Octanol, 3,7-dimethyl-, 1-acetate, 3,7-Dimethyl-1-octyl acetate, EC No.: 244-034-6 (+10 more)
INCI: DIHYDROCITRONELLYL ACETATE
Dihydrocitronellyl Acetate (CAS 20780-49-8) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 20780-49-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,7-dimethyloctyl acetate
InChIKey
XFPXWDJICXBWRU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no 21 CFR restriction; FEMA GRAS for flavour use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydrocitronellyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydrocitronellyl Acetate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5400 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [307] Epstein WL (1977): Report to RIFM, 7 October, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Dihydrocitronellyl Acetate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
Tetrahydrogeranyl acetate
1-Octanol, 3,7-dimethyl-, acetate
1-Octanol, 3,7-dimethyl-, 1-acetate
3,7-Dimethyl-1-octyl acetate
EC No.: 244-034-6
3,7-Dimethyl-1-octanol, acetate
3,7-Dimethyloctanyl acetate
3,7-Dimethyl-1-octanyl acetate
3,7-Dimethyloctanyl-1-acetate
3,7-Dimethyloctyl acetate
EINECS 244-034-6
3,7-Dimethyl-1-octanol acetate
244-034-6
MFCD00015056
BRN 1723170
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dihydrocitronellyl Acetate allowed in the EU?
Dihydrocitronellyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrocitronellyl Acetate do in cosmetics?
Dihydrocitronellyl Acetate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 20780-49-8.
Is Dihydrocitronellyl Acetate used outside cosmetics?
Dihydrocitronellyl Acetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydrocitronellyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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