Diethylenetriamine Pentamethylene Phosphonic Acid (CAS 15827-60-8) is a cosmetic cosmetic ingredient functioning as Chelating agent. NOAEL 82.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethylenetriamine Pentamethylene Phosphonic Acid is classified GHS Danger (H290, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
US NotesPermitted — no CFR restriction; widely used in personal care
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylenetriamine Pentamethylene Phosphonic Acid.
Calculate MoS for your specific formulation with the
MoS Calculator.
Toxicological Studies
1 study endpoint found for Diethylenetriamine Pentamethylene Phosphonic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=312 mg/kg bw/day
oral
Rat
reproduction developmental
ToxValDB_ECHA_IUCLID
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethylenetriamine Pentamethylene Phosphonic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Expert Verdict
Expert safety assessment and concern-level summary for Diethylenetriamine Pentamethylene Phosphonic Acid.
Public NOAEL study rows linked to Diethylenetriamine Pentamethylene Phosphonic Acid by CAS number or substance name.
Studies
1
Lowest NOAEL
312 mg/kg bw/day
Highest NOAEL
312 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
DTPMPEINECS 239-931-4UNII-0Q75589TM3
Chemical Function
Chelating agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status:listed
Frequently Asked Questions
Is Diethylenetriamine Pentamethylene Phosphonic Acid safe in cosmetics?
Diethylenetriamine Pentamethylene Phosphonic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is Diethylenetriamine Pentamethylene Phosphonic Acid allowed in the EU?
Diethylenetriamine Pentamethylene Phosphonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylenetriamine Pentamethylene Phosphonic Acid do in cosmetics?
Diethylenetriamine Pentamethylene Phosphonic Acid functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 15827-60-8.
What is the NOAEL for Diethylenetriamine Pentamethylene Phosphonic Acid?
The NOAEL (No Observed Adverse Effect Level) for Diethylenetriamine Pentamethylene Phosphonic Acid is =312 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Diethylenetriamine Pentamethylene Phosphonic Acid used outside cosmetics?
Diethylenetriamine Pentamethylene Phosphonic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethylenetriamine Pentamethylene Phosphonic Acid have different safety status in cosmetics vs industrial chemicals?
Diethylenetriamine Pentamethylene Phosphonic Acid is classified GHS Danger (H290, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Diethylenetriamine Pentamethylene Phosphonic Acid compliance across multiple jurisdictions:
Is Diethylenetriamine Pentamethylene Phosphonic Acid in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diethylenetriamine Pentamethylene Phosphonic Acid in your formulation.