Good Cosmetic Ingredient NOAEL Data

Diethylenetriamine Pentamethylene Phosphonic Acid

Also known as: DTPMP, EINECS 239-931-4, UNII-0Q75589TM3

INCI: DIETHYLENETRIAMINE PENTAMETHYLENE PHOSPHONIC ACID

Diethylenetriamine Pentamethylene Phosphonic Acid (CAS 15827-60-8) is a cosmetic cosmetic ingredient functioning as Chelating agent. NOAEL 82.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 15827-60-8 →

Auto-generated CPSR Part A draft with source citations
Function
Chelating agent
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C9H28N3O15P5
MW
573.2 g/mol
EC Number
239-931-4
PubChem CID
85128
IUPAC Name
[bis[2-[bis(phosphonomethyl)amino]ethyl]amino]methylphosphonic acid
InChIKey
DUYCTCQXNHFCSJ-UHFFFAOYSA-N

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted — no CFR restriction; widely used in personal care

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylenetriamine Pentamethylene Phosphonic Acid.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diethylenetriamine Pentamethylene Phosphonic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =312 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Diethylenetriamine Pentamethylene Phosphonic Acid across SCCS product categories, with measured dermal absorption where available.

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Chelating agent

Expert Verdict

Expert safety assessment and concern-level summary for Diethylenetriamine Pentamethylene Phosphonic Acid.

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Diethylenetriamine Pentamethylene Phosphonic Acid by CAS number or substance name.

Studies
1
Lowest NOAEL
312 mg/kg bw/day
Highest NOAEL
312 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

DTPMP EINECS 239-931-4 UNII-0Q75589TM3

Chemical Function

Chelating agent

Regulatory Lists

inert_ingredient; non_food_use; Pesticides

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Diethylenetriamine Pentamethylene Phosphonic Acid safe in cosmetics?

Diethylenetriamine Pentamethylene Phosphonic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Diethylenetriamine Pentamethylene Phosphonic Acid allowed in the EU?

Diethylenetriamine Pentamethylene Phosphonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylenetriamine Pentamethylene Phosphonic Acid do in cosmetics?

Diethylenetriamine Pentamethylene Phosphonic Acid functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 15827-60-8.

What is the NOAEL for Diethylenetriamine Pentamethylene Phosphonic Acid?

The NOAEL (No Observed Adverse Effect Level) for Diethylenetriamine Pentamethylene Phosphonic Acid is =312 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is Diethylenetriamine Pentamethylene Phosphonic Acid used outside cosmetics?

Diethylenetriamine Pentamethylene Phosphonic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Diethylenetriamine Pentamethylene Phosphonic Acid have different safety status in cosmetics vs industrial chemicals?

Diethylenetriamine Pentamethylene Phosphonic Acid is classified GHS Danger (H290, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.

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