Is Diethyl Sebacate safe in cosmetics?
Diethyl Sebacate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Diethyl Sebacate
Also known as: 4-02-00-02080, Bisoflex DES, BRN 1790779, Diethyl 1,10-decanedioate, Diethyl 1,8-octanedicarboxylate (+5 more)
INCI: DIETHYL SEBACATE
Diethyl Sebacate (CAS 110-40-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Emollient, Plasticizer, Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-40-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Emollient, Plasticizer, Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
diethyl decanedioate
InChIKey
ONKUXPIBXRRIDU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (December 2010, 7-1 vote) concluded safe as used in present practices and concentrations. Maximum reported use at time of CIR review was 1.5% in dermal contact products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Sebacate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
depigmentation
{"cas_number": "110-40-7", "ingredient_class": "other", "primary_mechanism_of_action": "Solvent/carrier enhancing brightening active delivery", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "onset_of_visible…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "10-11", "co_emulsifier_pairs": "polysorbate_80,ceteth_20", "optimal_oil_phase_pct": "10-28", "optimal_water_phase_pct": "72-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
624
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIETHYL 1,8-OCTANEDICARBOXYLATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIETHYL DECANEDIOATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL SEBACATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIETHYL SEBACATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Diethyl Sebacate.
Regulatory Flags
cir-safe
sensitization-risk
acd-case-reports
no-sccs-opinion
no-mos-calculated
penetration-enhancer
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-02080
Bisoflex DES
BRN 1790779
Diethyl 1,10-decanedioate
Diethyl 1,8-octanedicarboxylate
EINECS 203-764-5
Ethyl sebacate
FEMA No. 2376
NSC 8911
UNII-I41B9FJK6V
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1884461
Frequently Asked Questions
Is Diethyl Sebacate allowed in the EU?
Diethyl Sebacate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Sebacate do in cosmetics?
Diethyl Sebacate functions as: Skin Conditioning, Emollient, Plasticizer, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 110-40-7.
Is Diethyl Sebacate used outside cosmetics?
Diethyl Sebacate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethyl Sebacate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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