What is the NOAEL for Diethyl decanedioate?
Diethyl decanedioate has 9 NOAEL studies in the database. The lowest reported value is I41B9FJK6V UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethyl decanedioate
Also known as: diethyl sebacate, 4-02-00-02080, Bisoflex DES, BRN 1790779, Diethyl 1,10-decanedioate (+6 more)
CAS 110-40-7
Diethyl decanedioate (CAS 110-40-7) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Diethyl decanedioate
CAS Number
110-40-7
DTXSID
DTXSID0021915
Molecular Formula
C14H26O4
InChI Key
ONKUXPIBXRRIDU-UHFFFAOYSA-N
Monoisotopic Mass
258.183109
Synonyms
diethyl sebacate4-02-00-02080Bisoflex DESBRN 1790779Diethyl 1,10-decanedioateDiethyl 1,8-octanedicarboxylateEINECS 203-764-5Ethyl sebacateFEMA No. 2376NSC 8911UNII-I41B9FJK6V
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
SolventSoftener and conditionerPlasticizerDeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| I41B9FJK6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I41B9FJK6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I41B9FJK6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I41B9FJK6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =14470 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 15000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl sebacate | 203-764-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1884461
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Diethyl decanedioate?
Diethyl decanedioate appears on 5 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Diethyl decanedioate used in cosmetics?
Yes, Diethyl decanedioate is also indexed as a cosmetic ingredient under the name Diethyl Sebacate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethyl decanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethyl decanedioate used outside industrial chemicals?
Diethyl decanedioate also appears in cosmetics, pharmaceutical databases.