Is Diethoxydiglycol safe in cosmetics?
Diethoxydiglycol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Diethoxydiglycol
Also known as: BRN 1699259, EINECS 203-963-7, 1-Ethoxy-2-(beta-ethoxyethoxy)ethane, Glycol, diethylene-, diethyl ether, Diethylether diethylenglykolu (+5 more)
INCI: DIETHOXYDIGLYCOL
Diethoxydiglycol (CAS 112-36-7) is a cosmetic cosmetic ingredient functioning as Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 112-36-7 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
1-ethoxy-2-(2-ethoxyethoxy)ethane
InChIKey
RRQYJINTUHWNHW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR: safe as used at reported concentrations (up to 4–4.5% in leave-on)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethoxydiglycol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1151
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Diethoxydiglycol.
Known Synonyms
BRN 1699259
EINECS 203-963-7
1-Ethoxy-2-(beta-ethoxyethoxy)ethane
Glycol, diethylene-, diethyl ether
Diethylether diethylenglykolu
UNII-ZH086O935Z
1,5-diethoxy-3-oxapentane
Diethyldiethylene glycol
Ethyl diglyme
1-ethoxy-2-(2-ethoxyethoxy)ethane
Chemical Function
Solvent
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Diethoxydiglycol allowed in the EU?
Diethoxydiglycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethoxydiglycol do in cosmetics?
Diethoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-36-7.
Is Diethoxydiglycol used outside cosmetics?
Diethoxydiglycol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethoxydiglycol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Butoxydiglycol
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Chemical family
Solvent
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