What is the NOAEL for Diethylene glycol diethyl ether?
Diethylene glycol diethyl ether has 7 NOAEL studies in the database. The lowest reported value is 50.05 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethylene glycol diethyl ether
Also known as: BRN 1699259, EINECS 203-963-7, 1-Ethoxy-2-(beta-ethoxyethoxy)ethane, Glycol, diethylene-, diethyl ether, Diethylether diethylenglykolu (+5 more)
CAS 112-36-7
Diethylene glycol diethyl ether (CAS 112-36-7) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Diethylene glycol diethyl ether
CAS Number
112-36-7
DTXSID
DTXSID3025047
Molecular Formula
C8H18O3
InChI Key
RRQYJINTUHWNHW-UHFFFAOYSA-N
Monoisotopic Mass
162.125594
Synonyms
BRN 1699259EINECS 203-963-71-Ethoxy-2-(beta-ethoxyethoxy)ethaneGlycol, diethylene-, diethyl etherDiethylether diethylenglykoluUNII-ZH086O935Z1,5-diethoxy-3-oxapentaneDiethyldiethylene glycolEthyl diglyme1-ethoxy-2-(2-ethoxyethoxy)ethane
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes and skin. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =50.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| ZH086O935Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH086O935Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH086O935Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH086O935Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4970 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =9740 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis(2-ethoxyethyl) ether | 203-963-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1235106
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diethylene glycol diethyl ether?
Diethylene glycol diethyl ether appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Diethylene glycol diethyl ether used in cosmetics?
Yes, Diethylene glycol diethyl ether is also indexed as a cosmetic ingredient under the name Diethoxydiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethylene glycol diethyl ether come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethylene glycol diethyl ether used outside industrial chemicals?
Diethylene glycol diethyl ether also appears in cosmetics, pharmaceutical databases.