Is Dibutyl Adipate safe in cosmetics?
Dibutyl Adipate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Dibutyl Adipate
Also known as: Adimoll DB, Hexanedioic acid, 1,6-dibutyl ester, Adipic acid, dibutyl ester, Monocizer W 260, Adipic acid di-n-butyl ester (+14 more)
INCI: DIBUTYL ADIPATE
Dibutyl Adipate (CAS 105-99-7) is a cosmetic cosmetic ingredient functioning as Emollient, film forming, plasticizer, skin conditioning, solvent. NOAEL 178 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 105-99-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dibutyl Adipate is classified GHS CMR hazard (H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Emollient, film forming, plasticizer, skin conditioning, solvent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
dibutyl hexanedioate
InChIKey
XTJFFFGAUHQWII-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR Expert Panel concluded safe as used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibutyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Causes mild skin irritation Toxic to aquatic life
Short-term Exposure Effects
The substance is mildly irritating to the skin.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dibutyl Adipate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "10-11", "co_emulsifier_pairs": "polysorbate_80,ceteth_20", "optimal_oil_phase_pct": "10-28", "optimal_water_phase_pct": "72-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1705
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Plasticizer
Softener and conditioner
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Dibutyl Adipate.
Regulatory Flags
endocrine_disruptor
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dibutyl Adipate by CAS number or substance name.
Studies
30
Lowest NOAEL
125 mg/kg bw/day
Highest NOAEL
2399 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Adimoll DB
Hexanedioic acid, 1,6-dibutyl ester
Adipic acid, dibutyl ester
Monocizer W 260
Adipic acid di-n-butyl ester
Dibutyl hexanedioate
BRN 1790739
Butyl adipate
Cetiol B
EINECS 203-350-4
Experimental tick repellent 3
Experimental tick repellent 3PS
NSC 8086
Unitolate B
Polycizer W 260
Dibutylester kyseliny adipove
UNII-F4K100DXP3
Di-n-butyl adipate
Hexanedioic acid, dibutyl ester
Chemical Function
Solvent
Softener and conditioner
Film former
Plasticizer
Regulatory Lists
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188143
Frequently Asked Questions
Is Dibutyl Adipate allowed in the EU?
Dibutyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Adipate do in cosmetics?
Dibutyl Adipate functions as: Emollient, film forming, plasticizer, skin conditioning, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-99-7.
Is Dibutyl Adipate classified as hazardous under GHS?
Dibutyl Adipate carries a GHS signal word of "WARNING". Hazard statements: Causes mild skin irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Dibutyl Adipate used outside cosmetics?
Dibutyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dibutyl Adipate have different safety status in cosmetics vs industrial chemicals?
Dibutyl Adipate is classified GHS CMR hazard (H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dibutyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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