Is Dequalinium Acetate safe in cosmetics?
Dequalinium Acetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dequalinium Acetate
Also known as: Adenosine 5'-monophosphate disodium salt, Disodium 5'-O-phosphonatoadenosine, Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate, Adenylic acid disodium salt, AMP disodium salt (+6 more)
INCI: DEQUALINIUM ACETATE
Dequalinium Acetate (CAS 4578-31-8) is a cosmetic cosmetic ingredient functioning as Antimicrobial / preservative (quaternary ammonium compound). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4578-31-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial / preservative (quaternary ammonium compound)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
disodium;[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
InChIKey
QGXLVXZRPRRCRP-IDIVVRGQSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not specifically prohibited under 21 CFR; FDA lists dequalinium salts as pharmaceutical actives
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dequalinium Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Dequalinium Acetate.
Regulatory Flags
preservative
Known Synonyms
Adenosine 5'-monophosphate disodium salt
Disodium 5'-O-phosphonatoadenosine
Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Adenylic acid disodium salt
AMP disodium salt
5'-AMP disodium salt
Disodium AMP
Disodium 5'-AMP
EINECS 224-961-2
UNII-T1WZ11DSRN
Adenosine 5'-phosphate disodium
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dequalinium Acetate allowed in the EU?
Dequalinium Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dequalinium Acetate do in cosmetics?
Dequalinium Acetate functions as: Antimicrobial / preservative (quaternary ammonium compound). It is classified as a cosmetic ingredient in our database. CAS number: 4578-31-8.
Is Dequalinium Acetate used outside cosmetics?
Dequalinium Acetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dequalinium Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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