NOAEL Studies
Cosmetic Ingredient
Cyclopentadecanone NOAEL Studies
INCI: CYCLOPENTADECANONE
CAS: Commonly cited CAS for cyclopentadecanone macrocyclic ketone (exact CAS varies by isomer; RIFM safety assessment exists)
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=9c353b2b-0444-4488-a8cc-55f66a04cb88_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=9c353b2b-0444-4488-a8cc-55f66a04cb88/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e45b1462-0e55-440b-b17c-96651331889e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=9c353b2b-0444-4488-a8cc-55f66a04cb88_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=9c353b2b-0444-4488-a8cc-55f66a04cb88/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e45b1462-0e55-440b-b17c-96651331889e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=9c353b2b-0444-4488-a8cc-55f66a04cb88_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=9c353b2b-0444-4488-a8cc-55f66a04cb88/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e45b1462-0e55-440b-b17c-96651331889e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=846f8fa2-3059-44cb-93f5-f16fe856b445 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=345da0c5-c602-41af-9614-6ef0e18da437 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=846f8fa2-3059-44cb-93f5-f16fe856b445 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=345da0c5-c602-41af-9614-6ef0e18da437 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=846f8fa2-3059-44cb-93f5-f16fe856b445 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6z; document=0b8db2b1-a564-49ad-b407-77c334f4db4a_43e2af30-f6cd-4560-ae8e-d66e2841cd88.i6d; document_key=0b8db2b1-a564-49ad-b407-77c334f4db4a/43e2af30-f6cd-4560-ae8e-d66e2841cd88; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=345da0c5-c602-41af-9614-6ef0e18da437 |
NTP_ICE_skin_sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7571; Record_ID=skin_sensitization_invivo_1722; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047141; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80097-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047141 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6750 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7569; Record_ID=skin_sensitization_invivo_1722; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047141; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80097-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047141 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7573; Record_ID=skin_sensitization_invivo_1722; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047141; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80097-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047141 |
| NTP_ICE_skin_sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7578; Record_ID=skin_sensitization_invivo_1723; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047141; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2011; 21801795; 10.1016/j.fct.2011.07.040|McGinty et al. 2011; 21801797; 10.1016/j.fct.2011.07.041|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047141 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630902:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46c05945f20cf92de2f75af46476d1b8 |