Is Cyclohexyl Butyrate safe in cosmetics?
Cyclohexyl Butyrate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cyclohexyl Butyrate
Also known as: 4-06-00-00037, BRN 2083414, Cyclohexanyl butyrate, Cyclohexyl butanoate, EINECS 216-290-9 (+3 more)
INCI: CYCLOHEXYL BUTYRATE
Cyclohexyl Butyrate (CAS 1551-44-6) is a cosmetic cosmetic ingredient functioning as Fragrance / perfuming agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1551-44-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / perfuming agent.
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
cyclohexyl butanoate
InChIKey
VZHUBBUZNIULNM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - not prohibited or restricted; also has FEMA GRAS status for flavor use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclohexyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1094
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXYL BUTANOATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXYL BUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cyclohexyl Butyrate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-06-00-00037
BRN 2083414
Cyclohexanyl butyrate
Cyclohexyl butanoate
EINECS 216-290-9
FEMA No. 2351
NSC 53950
UNII-FHH53Z3I16
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cyclohexyl Butyrate allowed in the EU?
Cyclohexyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclohexyl Butyrate do in cosmetics?
Cyclohexyl Butyrate functions as: Fragrance / perfuming agent.. It is classified as a cosmetic ingredient in our database. CAS number: 1551-44-6.
Is Cyclohexyl Butyrate used outside cosmetics?
Cyclohexyl Butyrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cyclohexyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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