Is Cobamamide safe in cosmetics?
Cobamamide has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Cobamamide
Also known as: BRN 4122932, Cobalamine coenzyme, EINECS 237-627-6, Cobamamidum, 5,6-Dimethylbenzimidazolylcobamid coenzym (+1 more)
INCI: COBAMAMIDE
Cobamamide (CAS 13870-90-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin protecting, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 13870-90-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin protecting, skin conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate
InChIKey
OAJLVMGLJZXSGX-SLAFOUTOSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA UNII: F0R1QK73KB. Recognized as a form of vitamin B12. No restrictions for cosmetic use. Also has ATC code B03BA04 (pharmaceutical use).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cobamamide.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
2B, possibly carcinogenic to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Cobamamide.
Regulatory Flags
potential-allergen
Known Synonyms
BRN 4122932
Cobalamine coenzyme
EINECS 237-627-6
Cobamamidum
5,6-Dimethylbenzimidazolylcobamid coenzym
UNII-F0R1QK73KB
Chemical Function
Antioxidant
Humectant
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cobamamide allowed in the EU?
Cobamamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cobamamide do in cosmetics?
Cobamamide functions as: Antioxidant, skin protecting, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 13870-90-1.
Compliance Tools
Check Cobamamide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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