Is Citrus Grandis Seed Extract (Grapefruit Seed Extract) safe in cosmetics?
Citrus Grandis Seed Extract (Grapefruit Seed Extract) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Citrus Grandis Seed Extract (Grapefruit Seed Extract)
Also known as: Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus paradisi M., Rutaceae
INCI: CITRUS GRANDIS SEED EXTRACT
Citrus Grandis Seed Extract (Grapefruit Seed Extract) (CAS 90045-43-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning; antimicrobial; antioxidant. Extract obtained from the seeds. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 90045-43-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Citrus Grandis Seed Extract (Grapefruit Seed Extract) is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning; antimicrobial; antioxidant. Extract obtained from the seeds of the grapefruit, Citrus grandis (syn. Citrus paradisi). Contains flavonoids (naringenin, hesperidin), limonoids, and vitamin C precursors. Used in cosmetics as a skin conditioning and antioxidant active, with natural preservation-enhancing properties. Reported in 144 cosmetic product uses, with a majority in leave-on skin care preparations.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated by FDA for cosmetic use. Commercially marketed as a natural preservative booster; FDA has not issued any restriction. Formulators should ensure finished products comply with 21 CFR labeling and safety requirements.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citrus Grandis Seed Extract (Grapefruit Seed Extract).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Astringent
Deodorizer
Fragrance
Humectant
Softener and conditioner
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Citrus Grandis Seed Extract (Grapefruit Seed Extract).
Regulatory Flags
plant-extract
antioxidant
skin-conditioning
antimicrobial
cir-reviewed
botanical
flavonoids
grapefruit
fda_food_additive
Known Synonyms
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus paradisi M., Rutaceae
Chemical Function
Fragrance
Deodorizer
Softener and conditioner
Astringent
Regulatory Lists
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Grapefruit extract
Food Category
preservative
Frequently Asked Questions
Is Citrus Grandis Seed Extract (Grapefruit Seed Extract) allowed in the EU?
Citrus Grandis Seed Extract (Grapefruit Seed Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Citrus Grandis Seed Extract (Grapefruit Seed Extract) do in cosmetics?
Citrus Grandis Seed Extract (Grapefruit Seed Extract) functions as: Skin conditioning; antimicrobial; antioxidant. Extract obtained from the seeds of the grapefruit, Citrus grandis (syn. Citrus paradisi). Contains flavonoids (naringenin, hesperidin), limonoids, and vitamin C precursors. Used in cosmetics as a skin conditioning and antioxidant active, with natural preservation-enhancing properties. Reported in 144 cosmetic product uses, with a majority in leave-on skin care preparations.. It is classified as a cosmetic ingredient in our database. CAS number: 90045-43-5.
Is Citrus Grandis Seed Extract (Grapefruit Seed Extract) used outside cosmetics?
Citrus Grandis Seed Extract (Grapefruit Seed Extract) also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Citrus Grandis Seed Extract (Grapefruit Seed Extract) have different safety status in cosmetics vs industrial chemicals?
Citrus Grandis Seed Extract (Grapefruit Seed Extract) is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Citrus Grandis Seed Extract (Grapefruit Seed Extract) compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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