What is the NOAEL for Grapefruit, ext.?
Grapefruit, ext. has 1 NOAEL study in the database. The lowest reported value is 31.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Grapefruit, ext.
Also known as: Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus paradisi M., Rutaceae
CAS 90045-43-5
Grapefruit, ext. (CAS 90045-43-5) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Citrus Grandis Peel Extract →
Cross-Vertical Regulatory Divergence
Grapefruit, ext. is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics at max 5-MOP ≤15 ppm leave-on; 7-methoxycoumarin ≤100 ppm.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
1
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
4 fields
Name
Grapefruit, ext.
CAS Number
90045-43-5
DTXSID
DTXSID101020919
Synonyms
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus paradisi M., Rutaceae
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
FragranceDeodorizerSoftener and conditionerAstringentHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 1 of 1 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =31.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
Showing 1 of 1 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Grapefruit, ext. | 289-904-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
5-MOP ≤15 ppm leave-on; 7-methoxycoumarin ≤100 ppm
Category
Botanical
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Grapefruit, ext.?
Grapefruit, ext. appears on 3 regulatory/inventory lists including Europe; Personal care, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product. Source: EPA CPDat.
Is Grapefruit, ext. used in cosmetics?
Yes, Grapefruit, ext. is also indexed as a cosmetic ingredient under the name Citrus Grandis Peel Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Grapefruit, ext. come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Grapefruit, ext. have different safety status in cosmetics vs industrial chemicals?
Grapefruit, ext. is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics at max 5-MOP ≤15 ppm leave-on; 7-methoxycoumarin ≤100 ppm.
Is Grapefruit, ext. used outside industrial chemicals?
Grapefruit, ext. also appears in cosmetics, food safety databases.