Is cis-3-Hexenyl Cinnamate safe in cosmetics?
cis-3-Hexenyl Cinnamate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
cis-3-Hexenyl Cinnamate
Also known as: trans-2,cis-6-Nonadienal diethylacetal, EINECS 266-874-2, FEMA No. 3378, 2-trans-6-cis-Nonadienal diethyl acetal, 2-trans-6-cis-Nonadienal diethylacetal (+2 more)
INCI: CIS-3-HEXENYL CINNAMATE
cis-3-Hexenyl Cinnamate (CAS 67674-36-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (sweet, balsamic, green-floral). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 67674-36-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
cis-3-Hexenyl Cinnamate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient (sweet, balsamic, green-floral)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2E,6Z)-1,1-diethoxynona-2,6-diene
InChIKey
GCIRJCKOUVCUBZ-OFALOCIGSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
RIFM safety assessed; not individually CIR-reviewed; cleared via RIFM framework
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Cinnamate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
946
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,6-NONADIENAL DIETHYL ACETAL | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/107 | FAS 48-JECFA 57/369
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Cinnamate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
trans-2,cis-6-Nonadienal diethylacetal
EINECS 266-874-2
FEMA No. 3378
2-trans-6-cis-Nonadienal diethyl acetal
2-trans-6-cis-Nonadienal diethylacetal
trans-2,cis-6-Nonadienal diethyl acetal
UNII-V5C72V7U8P
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188466
Frequently Asked Questions
Is cis-3-Hexenyl Cinnamate allowed in the EU?
cis-3-Hexenyl Cinnamate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Cinnamate do in cosmetics?
cis-3-Hexenyl Cinnamate functions as: Fragrance ingredient (sweet, balsamic, green-floral). It is classified as a cosmetic ingredient in our database. CAS number: 67674-36-6.
Is cis-3-Hexenyl Cinnamate used outside cosmetics?
cis-3-Hexenyl Cinnamate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does cis-3-Hexenyl Cinnamate have different safety status in cosmetics vs industrial chemicals?
cis-3-Hexenyl Cinnamate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319).
Compliance Tools
Check cis-3-Hexenyl Cinnamate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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