Is cis-3-Hexenyl Anthranilate safe in cosmetics?
cis-3-Hexenyl Anthranilate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
cis-3-Hexenyl Anthranilate
Also known as: 3-Hexen-1-ol, 1-(2-aminobenzoate), (3Z)-, 3-Hexen-1-ol, 2-aminobenzoate, (3Z)-, 3-Hexen-1-ol, 2-aminobenzoate, (Z)-, 3-Hexen-ol, 2-aminobenzoate, (Z)-
INCI: CIS-3-HEXENYL ANTHRANILATE
cis-3-Hexenyl Anthranilate (CAS 65405-76-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with fruity, green, grape-like notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 65405-76-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with fruity, green, grape-like notes
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] 2-aminobenzoate
InChIKey
VZWCCPAVZNSCEO-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not individually CIR-reviewed; cleared via RIFM safety assessment; FEMA GRAS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Anthranilate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1538
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXENYL ANTHRANILATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | No safety concern (conditional) at current levels of intake when used as a flavouring agent. The evaluation is conditional because the estimated daily intake is based on the anticipated annual volume of production. The conclusion of the safety evaluation of this substance will be rev
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Anthranilate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
3-Hexen-1-ol, 1-(2-aminobenzoate), (3Z)-
3-Hexen-1-ol, 2-aminobenzoate, (3Z)-
3-Hexen-1-ol, 2-aminobenzoate, (Z)-
3-Hexen-ol, 2-aminobenzoate, (Z)-
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
(Z)-3-HEXENYL ANTHRANILATE
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl Anthranilate allowed in the EU?
cis-3-Hexenyl Anthranilate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Anthranilate do in cosmetics?
cis-3-Hexenyl Anthranilate functions as: Fragrance ingredient with fruity, green, grape-like notes. It is classified as a cosmetic ingredient in our database. CAS number: 65405-76-7.
Is cis-3-Hexenyl Anthranilate used outside cosmetics?
cis-3-Hexenyl Anthranilate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Anthranilate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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