Also known as: TiO2, Atlas white titanium dioxide, Blend White 9202, Brookite, Calcotone White T (+15 more)
INCI: CI 77891
CI 77891 (Titanium Dioxide) (CAS 13463-67-7) is a cosmetic cosmetic ingredient functioning as Colorant; UV Filter; Opacifying Agent. Inorganic pigment (TiO2) used as a white. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 25% as UV filter; 1.4% in hair aerosol sprays for consumers, 1.1% for professional use; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 13463-67-7 →
CI 77891 (Titanium Dioxide) is classified GHS CMR hazard (H351) in the chemicals database but is restricted in EU cosmetics at max 25% as UV filter; 1.4% in hair aerosol sprays for consumers, 1.1% for professional use.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77891 (Titanium Dioxide).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for CI 77891 (Titanium Dioxide). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | =250 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =250 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =260 mg/kg bw/day | - | Mouse | Chronic toxicity | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =260 mg/kg bw/day | - | Mouse | Chronic toxicity | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =1251 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =1251 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v1051je01 |
| NOAEL | =62.5 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
. The CIR Expert Panel concluded that dimethicone is safe in cosmetics in the present practices of use and reported concentration ranges when formulated to be non- irritating, with the exception that the available data are insufficient to make a determination of safety for use in products that
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
n light of this and given the many uncertainties, the panel concluded that E171 should no longer be considered as safe when used as a food additive. In May 2022, the Commission services received a dossier submission by industry accompanied by a comprehensive and up to date review of the genetic toxicity database fo
Pre-calculated NOAEL → SED → MoS audit trail for CI 77891 (Titanium Dioxide) across SCCS product categories, with measured dermal absorption where available.
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =2250 mg/kg-day | Rat | oral | chronic | EFSA |
| LC50 | >2280 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LC50 | =5090 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LC50 | =3430 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LC50 | >3560 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LC50 | >6820 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >25000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >5000 mg/kg | Mouse | oral | - | ECHA IUCLID |
| LD50 | >5000 mg/kg | Rat | oral | - | ECHA IUCLID |
International Agency for Research on Cancer (WHO) monograph evaluation.
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
weak modulator (oxidative stress pathway)
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 25 | Rinse-off and leave-on products (UV use) |
| CN | permitted_uv_filter | 25 | All cosmetics (no aerosol for nano) |
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| IN | permitted_uv_filter | 25.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 25 | Sunscreen products; nano form NOT permitted in Brazil (unlike EU) |
| BR | permitted_colorant | - | Column 1: All cosmetic products |
| UK | restricted | - | - |
| ASEAN | permitted_uv_filter | 25% | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vitro | 0.0 | In vivo — human & animal studies (tape-stripping, histology, ICP-MS) | - | SCCS/1516/13 (2013) (2013) |
| measured_in_vitro | 0.03 | - | - | SCCS/1516/13 |
| measured_in_vitro | 0.175 | - | - | SCCS/1516/13 |
| measured_in_vitro | 0.03 | - | - | SCCS/1516/13 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for CI 77891 (Titanium Dioxide).
Public NOAEL study rows linked to CI 77891 (Titanium Dioxide) by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.0 | In vivo — human & animal studies (tape-stripping, histology, ICP-MS) | Sunscreen formulations (various) |
| 0.03 | - | - |
| 0.175 | - | - |
| 0.03 | - | - |
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
CI 77891 (Titanium Dioxide) has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
CI 77891 (Titanium Dioxide) EU regulatory status: restricted. Maximum allowed concentration: 25% as UV filter; 1.4% in hair aerosol sprays for consumers, 1.1% for professional use. This is based on EU Regulation 1223/2009 and its amendments.
CI 77891 (Titanium Dioxide) functions as: Colorant; UV Filter; Opacifying Agent. Inorganic pigment (TiO2) used as a white colorant and opacity agent in foundations, sunscreens, face powders, eye shadows, lipsticks, and toothpaste. Functions as a physical UV filter in sunscreen formulations. Produced synthetically in anatase or rutile crystal forms.. It is classified as a cosmetic ingredient in our database. CAS number: 13463-67-7.
The NOAEL (No Observed Adverse Effect Level) for CI 77891 (Titanium Dioxide) is 1250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
CI 77891 (Titanium Dioxide) carries a GHS signal word of "DANGER". Hazard statements: Causes damage to respiratory system through prolonged or repeated exposure if inhaled Suspected of causing cancer. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
CI 77891 (Titanium Dioxide) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
CI 77891 (Titanium Dioxide) is classified GHS CMR hazard (H351) in the chemicals database but is restricted in EU cosmetics at max 25% as UV filter; 1.4% in hair aerosol sprays for consumers, 1.1% for professional use.
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