Is CI 45396 safe in cosmetics?
CI 45396 has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
CI 45396
Also known as: EINECS 246-308-0
CI 45396 (CAS 24545-86-6) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: permitted, max 1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 24545-86-6 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3',6'-dihydroxy-4',5'-dinitrospiro[2-benzofuran-3,9'-xanthene]-1-one
InChIKey
RYCIBGACBRAXBM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
1%
US US Status
prohibited
US Notes
Not listed as an approved FDA D&C or FD&C color additive for cosmetics in the US.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 45396.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Orange
1%, when used in lip products
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
Max: 1%, when used in lip products.
BRIN Brazil/India Cosmetics
India: Permitted Colorant · max 1%, when used in lip products
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 45396.
Regulatory Flags
max-1-percent-lip-products
free-acid-form-lip-products
not-fda-approved
synthetic-dye
solvent-orange-16
eu_cosing_listed
Known Synonyms
EINECS 246-308-0
Chemical Function
Dye
Regulatory Lists
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is CI 45396 allowed in the EU?
CI 45396 EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 45396 do in cosmetics?
CI 45396 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 24545-86-6.
Is CI 45396 used outside cosmetics?
CI 45396 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 45396 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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