Is CI 45220 safe in cosmetics?
CI 45220 has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
CI 45220
Also known as: Hydrogen 9-(2,4-disulphonatophenyl)-3,6-bis(ethylamino)-2,7-dimethylxanthylium, monosodium sal, Xanthylium, 9-(2,4-disulfophenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, inner salt, monosodium salt, Xanthylium, 9-(2,4-disulfophenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, inner salt, sodium salt (1:1)
CI 45220 (CAS 5873-16-5) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5873-16-5 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
sodium 4-[3-(ethylamino)-6-ethylazaniumylidene-2,7-dimethylxanthen-9-yl]benzene-1,3-disulfonate
InChIKey
NWWFZBYHUXCUDI-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not listed as an approved FDA D&C or FD&C color additive for cosmetics in the US.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 45220.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
Product type: Rinse-off products.
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for CI 45220.
Regulatory Flags
rinse-off-only
not-fda-approved
synthetic-dye
xanthene-dye
sulforhodamine-class
Known Synonyms
Hydrogen 9-(2,4-disulphonatophenyl)-3,6-bis(ethylamino)-2,7-dimethylxanthylium, monosodium sal
Xanthylium, 9-(2,4-disulfophenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, inner salt, monosodium salt
Xanthylium, 9-(2,4-disulfophenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, inner salt, sodium salt (1:1)
Chemical Function
Dye
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 45220 allowed in the EU?
CI 45220 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 45220 do in cosmetics?
CI 45220 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 5873-16-5.
Is CI 45220 used outside cosmetics?
CI 45220 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 45220 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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