NOAEL Studies Cosmetic Ingredient

CI 28440 NOAEL Studies

CAS: 2519-30-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2010 - OutputID 412 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive - doi:10.2903/j.efsa.2010.1540
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2010 - OutputID 412 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive - doi:10.2903/j.efsa.2010.1540
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2010 - OutputID 412 - Consumers - Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive - doi:10.2903/j.efsa.2010.1540
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2010 - OutputID 412 - Consumers - Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive - doi:10.2903/j.efsa.2010.1540
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4610; row=3744; data_type=In Vivo; mixture=Chemical; chemical_name=Black PN; preferred_name=C.I. Food Black 1, tetrasodium salt; dtxsid=DTXSID2020183; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020183; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3bdb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/8?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15820117:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f28fe4f0dd6a8076098df1e9519513b
ToxValDB_ECHA_IUCLID NOAEL =1300 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3bd9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/8?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15820086:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_15b031b75e3349d5c99560f8231c7b4d
ToxValDB_ECHA_IUCLID NOAEL =1500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaac3e4b0a7c65d1b75e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21583/7/9/2?documentUUID=2f5ce440-67ff-4f67-a435-888350d4c19d; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=F2: viability|F2: sexual maturation|F2: clinical signs|F2: mortality|F2: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|development|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860827_15861259_15861541:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f684290ff2368cdcadf9e3c2f0af032
ToxValDB_ECHA_IUCLID NOAEL =2000 mg/kg bw/day Rat dermal subchronic; 10 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ed5e4b096bca877b295; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/6/4?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15826644:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62bb97307ae7019704603d0928ab0fdb
ToxValDB_ECHA_IUCLID NOEL =100 mg/kg bw/day Pig oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8e8e4b0a7c65d21a9a4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/2?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15857113:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_058517c962011b33b5862a019237ccbb
ToxValDB_ECHA_IUCLID NOEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/2?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855354_15862477:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d0f0a5d6b368690fba293678d647c9b0
ToxValDB_ECHA_IUCLID NOEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/2?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861210_15861287:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6dc3b22ac54e9ffefd892ddead6b6762
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/2?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856184_15860513:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eadabe3eb5efbaa9a03d15b436709c02
ToxValDB_ECHA_IUCLID NOEL =1300 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/2?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15860993:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a3ea3199f7498f8d096ff5858f432aad
ToxValDB_ECHA_IUCLID NOEL =2500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17303/7/9/3?documentUUID=3171a717-d462-499b-8dfd-005ee146fc96; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15824633:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4012bd123ac85a56f866e03f0279d8c0
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =500 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA ANS (2010). Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive. doi:10.2903/j.efsa.2010.1540.; TITLE=Scientific Opinion on the re-evaluationof Brilliant Black BN (E 151) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2010.1540; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614331:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a650d60f9330401eb314746f196b6bb
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=1 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb36e4b0d99f5a87a6f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/130; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=WHO JECFA ADI:15715323:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f98c29554a985c0cdd961d864e933aac
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2WPR32U0CP UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H17N5O14S4.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2WPR32U0CP"}
openFDA substances FDA UNII substance identifier 2WPR32U0CP UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H17N5O14S4.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2WPR32U0CP"}
openFDA substances FDA UNII substance identifier 2WPR32U0CP UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H17N5O14S4.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2WPR32U0CP"}
openFDA substances FDA UNII substance identifier 2WPR32U0CP UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H17N5O14S4.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2WPR32U0CP"}