Is CI 15985 safe in cosmetics?
CI 15985 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
CI 15985
Also known as: C.I. 15985, C.I. Food Yellow 3, 2-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium salt, D and C Yellow 6, L. Orange Z2010 (+15 more)
CI 15985 (CAS 2783-94-0) is a cosmetic cosmetic ingredient functioning as Colorant (yellow). NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 2783-94-0 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (yellow)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate
InChIKey
OIQPTROHQCGFEF-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted – FD&C Yellow No. 6 (permanently listed, certification required)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 15985.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 15985. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 243 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | =0.005 mg/kg bw | - | Rat | Acute toxicity | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.005 mg/kg bw | - | Rat | Acute toxicity | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.01 mg/kg bw/day | oral | - | Neurotoxicity | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.01 mg/kg bw/day | oral | - | Neurotoxicity | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.01 mg/kg bw/day | oral | - | Neurotoxicity | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.02 mg/kg bw/day | oral | Rabbit | Toxicology study | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.02 mg/kg bw/day | oral | Rabbit | Toxicology study | INCHEM_WHO_jecfa_jecmono_v65je01 |
| NOAEL | =0.02 mg/kg bw/day | oral | Rabbit | Toxicology study | INCHEM_WHO_jecfa_jecmono_v65je01 |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 15985 across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =148 mg/kg-day | Mouse | oral | chronic | ECHA IUCLID |
| NOAEL | =148 mg/kg-day | Mouse | oral | chronic | ECHA IUCLID |
| NOAEL | =500 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =500 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =500 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =375 mg/kg-day | Rat | oral | short-term | EFSA |
| LOEL | =1000 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =250 mg/kg-day | Mouse | oral | - | ECHA IUCLID |
| NOAEL | =250 mg/kg-day | Mouse | oral | - | ECHA IUCLID |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
8, Sup 7
Evaluation Year
1987
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "FD&C Yellow No. 6", "Chemical_Name": "Sunset Yellow FCF", "CAS_Number": "2783-94-0", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.706", "Notes": "Water-soluble, good stability"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CI 15985.
Regulatory Flags
colorant
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 15985 by CAS number or substance name.
Studies
71
Lowest NOAEL
0.005
Highest NOAEL
6000
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg diet
INCHEM_WHO_jecfa_jecmono_v65je01
ToxValDB_ECHA_IUCLID
COSMOS_DB
Known Synonyms
C.I. 15985
C.I. Food Yellow 3
2-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium salt
D and C Yellow 6
L. Orange Z2010
A.F. Yellow No. 5
Aizen Food Yellow No. 5
Disodium 6-hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonate
Disodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acid
Dye FDC Yellow No. 6
Dye Sunset Yellow
EINECS 220-491-7
FD and C No. 6
6-Hydroxy-5-((p-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium salt
6-Hydroxy-5-((p-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium salt
6-Hydroxy-5-((4-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium salt
2-Naphthalenesulfonic acid, 6-hydroxy-5-((4-sulfophenyl)azo)-, disodiumsalt
NCI-C53907
Orange Yellow S. AF
Orange Yellow S. FQ
Chemical Function
Dye
Fragrance
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care
children; Europe; Personal care
general_foods
pharmaceutical
Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
E110
ChEMBL ID
CHEMBL1371409
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sunset Yellow FCF (FD&C Yellow 6)
E Number
E110
ADI
4 mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is CI 15985 allowed in the EU?
CI 15985 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 15985 do in cosmetics?
CI 15985 functions as: Colorant (yellow). It is classified as a cosmetic ingredient in our database. CAS number: 2783-94-0.
What is the NOAEL for CI 15985?
The NOAEL (No Observed Adverse Effect Level) for CI 15985 is 243 mg/kg bw/day based on a Reproductive study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is CI 15985 used outside cosmetics?
CI 15985 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 15985 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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CI 15985 Yellow 6 Lake
Moderate
Chemical family
cosmetic colorant
CI 10006
Moderate
Browse nearby
Colorant (green)
CI 10020
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