What is the NOAEL for FD&C Yellow 6?
FD&C Yellow 6 has 100 NOAEL studies in the database. The lowest reported value is 1.38e-7 fraction in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
FD&C Yellow 6
Also known as: C.I. 15985, C.I. Food Yellow 3, 2-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium salt, D and C Yellow 6, L. Orange Z2010 (+15 more)
CAS 2783-94-0
FD&C Yellow 6 (CAS 2783-94-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
FD&C Yellow 6
CAS Number
2783-94-0
DTXSID
DTXSID6021456
Molecular Formula
C16H12N2O7S2.2Na
InChI Key
OIQPTROHQCGFEF-UHFFFAOYSA-L
Monoisotopic Mass
453.988132
Synonyms
C.I. 15985C.I. Food Yellow 32-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium saltD and C Yellow 6L. Orange Z2010A.F. Yellow No. 5Aizen Food Yellow No. 5Disodium 6-hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonateDisodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acidDye FDC Yellow No. 6Dye Sunset YellowEINECS 220-491-7
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 8, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.1250.125 | mg/kg bw/day | ADI | oral | Mouse | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.1250.125 | mg/kg bw/day | ADI | oral | Mouse | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.750.75 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.750.75 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-11 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v65je01 |
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| range:0-11 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-44 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v65je01 |
| =4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| range:0-44 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-1010 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| range:0-1010 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| =50 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| =50 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v65je01 |
| =1 | mg/kg bw/day | ADI (provisional) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ADI (provisional) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 18.9 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1469.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H77VEI93A8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H77VEI93A8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H77VEI93A8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H77VEI93A8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.38e-7 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =625 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =625 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =900 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =900 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >1250 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =3750 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =3750 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1.35 | mg/kg bw/day | LOAEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v65je01 |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate | 220-491-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
3%
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
E110
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E110 — ADI: 4 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include FD&C Yellow 6?
FD&C Yellow 6 appears on 10 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, and 7 more. Source: EPA CPDat.
Is FD&C Yellow 6 a carcinogen according to IARC?
FD&C Yellow 6 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is FD&C Yellow 6 used in cosmetics?
Yes, FD&C Yellow 6 is also indexed as a cosmetic ingredient under the name CI 15985 Yellow 6 Lake. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for FD&C Yellow 6 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is FD&C Yellow 6 used outside industrial chemicals?
FD&C Yellow 6 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.