Good Preservative NOAEL Data Sensitization Data

Chamomile Extract (Matricaria Chamomilla Extract)

INCI: MATRICARIA CHAMOMILLA EXTRACT

Chamomile Extract (Matricaria Chamomilla Extract) (CAS 84082-60-0) is a cosmetic preservative functioning as Preservative. Reported NOAEL =200 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.

View industrial chemical safety profile for CAS 84082-60-0 →

Auto-generated CPSR Part A draft with source citations
Function
Preservative
Safety Rating
GOOD

Chemistry & Identifiers

EC Number
282-006-5

Regulatory Status

EU EU Status permitted
US US Status permitted

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Chamomile Extract (Matricaria Chamomilla Extract).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Chamomile Extract (Matricaria Chamomilla Extract). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =200 mg/kg/d oral rat oral toxicity CIR_vision_codex
NOAEL =200 mg/kg/d oral rat oral toxicity CIR_vision_codex
NOAEL =200 mg/kg/d oral rat oral toxicity CIR_vision_codex
NOAEL =200 mg/kg/d oral rat oral toxicity CIR_vision_codex

Sensitization Profile

Contact sensitization data for Chamomile Extract (Matricaria Chamomilla Extract) based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
compositae-group
Reaction Type
contact-dermatitis

Source: IVDK; literature review

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Additional Ingredient Properties

1 property record from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "botanical", "cross_reactivity_group": "compositae-group", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; literature review"}

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (2)
EU Regulated in Personal Care EU Restricted for Children (Cosmetics)

Expert Verdict

Expert safety assessment and concern-level summary for Chamomile Extract (Matricaria Chamomilla Extract).

Regulatory Flags

eu_children_restricted

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Chamomile Extract (Matricaria Chamomilla Extract) by CAS number or substance name.

Studies
4
Lowest NOAEL
200 mg/kg/d
Highest NOAEL
200 mg/kg/d
CIR_vision_codex

Chemical Function

Deodorizer Softener and conditioner Fragrance

Regulatory Lists

children; Europe; Personal care children; Europe; Personal care - hair styling and care - shampoo children; Europe; Personal care - specialized bath products - bubble bath children; Europe; Personal care - dental care - toothpaste Europe; Personal care - hair styling and care - shampoo-dandruff Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA count match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Adverse Event Associations
58
View full pharmaceutical profile →

Frequently Asked Questions

Is Chamomile Extract (Matricaria Chamomilla Extract) safe in cosmetics?

Chamomile Extract (Matricaria Chamomilla Extract) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.

Is Chamomile Extract (Matricaria Chamomilla Extract) allowed in the EU?

Chamomile Extract (Matricaria Chamomilla Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Chamomile Extract (Matricaria Chamomilla Extract) do in cosmetics?

Chamomile Extract (Matricaria Chamomilla Extract) functions as: Preservative. It is classified as a Preservative in our database. CAS number: 84082-60-0.

What is the NOAEL for Chamomile Extract (Matricaria Chamomilla Extract)?

The NOAEL (No Observed Adverse Effect Level) for Chamomile Extract (Matricaria Chamomilla Extract) is =200 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.

Is Chamomile Extract (Matricaria Chamomilla Extract) used outside cosmetics?

Chamomile Extract (Matricaria Chamomilla Extract) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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