Is Chamomile Extract safe in cosmetics?
Chamomile Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Chamomile Extract
INCI: MATRICARIA CHAMOMILLA FLOWER EXTRACT
Chamomile Extract (CAS 84082-60-0) is a cosmetic active ingredient functioning as Anti-inflammatory; bisabolol, chamazulene. Reported NOAEL =200 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 84082-60-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chamomile Extract is classified GHS Danger (H304, H315, H317, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Anti-inflammatory; bisabolol, chamazulene
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA. GRAS under 21 CFR Parts 182 and 184 for food/flavor use. FDA determined data inadequate to support OTC drug use. CIR 2018 Amended Safety Assessment concluded safe when formulated to be nonsensitizing. Industry practice up to 0.5% extract in leave-on products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chamomile Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Chamomile Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Bioactive phytochemicals, antioxidant compounds", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Phyt…
depigmentation
{"cas_number": "84082-60-0", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Multiple phytocompounds provide tyrosinase inhibition and antioxidant brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reductio…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Chamomile Extract.
Regulatory Flags
asteraceae-cross-reactivity
sensitization-in-allergy-prone
botanical-complex-mixture
no-formal-dermal-absorption-data
gras-food-grade
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Chamomile Extract by CAS number or substance name.
Studies
4
Lowest NOAEL
200 mg/kg/d
Highest NOAEL
200 mg/kg/d
CIR_vision_codex
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care - dental care - toothpaste
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
58
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Chamomile extract
Food Category
preservative
Frequently Asked Questions
Is Chamomile Extract allowed in the EU?
Chamomile Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Chamomile Extract do in cosmetics?
Chamomile Extract functions as: Anti-inflammatory; bisabolol, chamazulene. It is classified as a Active Ingredient in our database. CAS number: 84082-60-0.
What is the NOAEL for Chamomile Extract?
The NOAEL (No Observed Adverse Effect Level) for Chamomile Extract is =200 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Is Chamomile Extract used outside cosmetics?
Chamomile Extract also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chamomile Extract have different safety status in cosmetics vs industrial chemicals?
Chamomile Extract is classified GHS Danger (H304, H315, H317, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Chamomile Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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