Moderate Cosmetic Ingredient NOAEL Data

Ceteth-24

Also known as: Hexadecylpoly(ethyleneoxy)ethanol, Oxyethylenated hexadecyl alcohol, Polyethylene glycol cetyl ether, Poly(oxy-1,2-ethanediyl), alpha-hexadecyl-omega-hydroxy-, Cetomacrogol (+14 more)

INCI: CETETH-24

Ceteth-24 (CAS 9004-95-9) is a cosmetic cosmetic ingredient functioning as Emulsifying, Cleansing, Solubilizing. Reported NOAEL =300 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 9004-95-9 →

Auto-generated CPSR Part A draft with source citations
Function
Emulsifying, Cleansing, Solubilizing
Safety Rating
MODERATE

Chemistry & Identifiers

Formula
C56H114O21
MW
1123.5 g/mol
EC Number
500-014-1
PubChem CID
2724259
IUPAC Name
2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
InChIKey
NLMKTBGFQGKQEV-UHFFFAOYSA-N

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes CIR 1999: specifically named — safe in the present practices of use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Ceteth-24.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Ceteth-24. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =300 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Cleaning agent Emulsifier Surfactant (surface active agent) Wetting agent (non-aqueous)
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL) FDA Indirect Food Contact Additives

Expert Verdict

Expert safety assessment and concern-level summary for Ceteth-24.

Regulatory Flags

epa_safer_alternative

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Ceteth-24 by CAS number or substance name.

Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

Hexadecylpoly(ethyleneoxy)ethanol Oxyethylenated hexadecyl alcohol Polyethylene glycol cetyl ether Poly(oxy-1,2-ethanediyl), alpha-hexadecyl-omega-hydroxy- Cetomacrogol Poly(oxy-1,2-ethanediyl), .alpha.-hexadecyl-.omega.-hydroxy- Cetyl poly(oxyethylene) ether Ethosperse CL20 Hexadecylpoly(ethyleneoxy) ethanol Polyethylene glycols monohexadecyl ether Poly(oxyethylene)cetyl ether Poly(oxyethylene)hexadecyl ether Poly(oxyethylene)monocetyl ether Poly(oxyethylene)palmityl ether alpha-Hexadecyl-omega-hydroxy-poly(oxy-1,2-ethanediyl) alpha-Hydroxy-omega-cetylpoly(ethylene oxide) Cetomacrogolum 1000 UNII-I835H2IHHX UNII-LF9X1PN3XJ

Chemical Function

Surfactant (surface active agent)

Regulatory Lists

Europe; Personal care - liniment pharmaceutical SCIL (9/2019) Indirect additives food contact (10/2018) inert_ingredient; Pesticides inert_ingredient; non_food_use; Pesticides

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Ceteth-24 safe in cosmetics?

Ceteth-24 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Ceteth-24 allowed in the EU?

Ceteth-24 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ceteth-24 do in cosmetics?

Ceteth-24 functions as: Emulsifying, Cleansing, Solubilizing. It is classified as a cosmetic ingredient in our database. CAS number: 9004-95-9.

What is the NOAEL for Ceteth-24?

The NOAEL (No Observed Adverse Effect Level) for Ceteth-24 is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is Ceteth-24 used outside cosmetics?

Ceteth-24 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Ceteth-24 have different safety status in cosmetics vs industrial chemicals?

Ceteth-24 is classified GHS Danger (H315, H302, H318) in the chemicals database but is allowed in EU cosmetics.

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