Is Ceramide EOP safe in cosmetics?
Ceramide EOP has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ceramide EOP
INCI: CERAMIDE EOP
Ceramide EOP (CAS 123404-97-7) is a cosmetic cosmetic ingredient functioning as Ceramide 1 (acylceramide with linoleic acid esterification). Critical for. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 123404-97-7 →
Auto-generated CPSR Part A draft with source citations
Function
Ceramide 1 (acylceramide with linoleic acid esterification). Critical for lamellar body secretion and intercellular lipid organisation. Deficiency linked to atopic dermatitis and compromised barrier. Provides lipid anchoring between lamellar bilayers in stratum corneum. Part of ceramide:cholesterol:fatty acid triple-lipid system. Barrier function, TEWL reduction, and anti-atopic activity.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR 2020 safe as used. Commercial supply synthetic or biotech-derived. FDA BSE restriction does not apply to synthetic ceramides.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide EOP.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ceramide EOP, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
1050.6 Da
Log P
14.5
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: J Lipid Res 2014
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 3 | Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "100403-19-8", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,sensitive,combination,normal,mature,rosacea", "acne_safe": "yes", "source": "Skin-identical lipid"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.3", "product_type": "Serum", "function_at_concentration": "Barrier integrity", "source": "Clinical literature"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "550", "estimated_cost_per_kg_usd_high": "1000", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "Japan/Europe", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Cerami…
dermal_absorption
{"molecular_weight_da": "1050.6", "log_p_value": "14.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "minimal", "…
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "balanced", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens"…
humectant
{"cas_number": "100403-19-8", "ingredient_class": "emollient/ceramide_precursor", "molecular_weight_Da": "1000-1200", "chemical_type": "lipid", "water_binding_mechanism": "intercellular_lipid", "water_holding_capacity_g_per_g": "0", "hygroscopicity_at_50_RH": "poor", "hygroscopicity_at_80_RH": "poor", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_reduction_pct": "20-32", "skin_hydrat…
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide EOP.
Regulatory Flags
barrier-lipid
ceramide
acylceramide
long-periodicity-phase
linoleic-acid-ester
phytosphingosine-backbone
trilipid-triad
3:1:1-elias-ratio
atopic-dermatitis-target
scorad-improvement
steroid-sparing
peds-fda-510k
cir-reviewed
oxidation-sensitive
Frequently Asked Questions
Is Ceramide EOP allowed in the EU?
Ceramide EOP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide EOP do in cosmetics?
Ceramide EOP functions as: Ceramide 1 (acylceramide with linoleic acid esterification). Critical for lamellar body secretion and intercellular lipid organisation. Deficiency linked to atopic dermatitis and compromised barrier. Provides lipid anchoring between lamellar bilayers in stratum corneum. Part of ceramide:cholesterol:fatty acid triple-lipid system. Barrier function, TEWL reduction, and anti-atopic activity.. It is classified as a cosmetic ingredient in our database. CAS number: 123404-97-7.
Compliance Tools
Check Ceramide EOP compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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