Is Ceramide AP safe in cosmetics?
Ceramide AP has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ceramide AP
INCI: CERAMIDE AP
Ceramide AP (CAS 154756-45-3) is a cosmetic cosmetic ingredient functioning as Ceramide barrier lipid, skin-conditioning agent. Part of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 154756-45-3 →
Auto-generated CPSR Part A draft with source citations
Function
Ceramide barrier lipid, skin-conditioning agent. Part of ceramide:cholesterol:fatty acid triple-lipid system. Strengthens skin barrier, reduces water loss, supports healthy skin.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR 2020 safe as used. Commercial supply synthetic or biotech-derived. BSE restriction does not apply.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide AP.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ceramide AP, relevant to systemic exposure and MoS calculations.
Absorption %
2-6%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
630.0 Da
Log P
10.2
Systemic Absorption
minimal
Topical Bioavailability
1-4%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: J Lipid Res 2014
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 3 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "114616-44-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5/urban_pollutants", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "n…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,sensitive,combination,normal,mature,rosacea", "acne_safe": "yes", "source": "Skin-identical lipid"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "3.0", "typical_concentration_pct": "1.0", "product_type": "Serum", "function_at_concentration": "Barrier repair", "source": "Clinical literature"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "480", "estimated_cost_per_kg_usd_high": "900", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "Japan/Europe", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Ceramid…
dermal_absorption
{"molecular_weight_da": "630.0", "log_p_value": "10.2", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "2-6", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "1-4", "safety_margin_factor": "low", "source"…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "w_o", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "cholesterol,ceramide_np", "optimal_oil_phase_pct": "55-85", "optimal_water_phase_pct": "15-45", "droplet_size_range_um": "3-35", "creaming_resistance": "moderate", "coalescence_resistance": "excellent", "ostwald_ripening_resistance": "excellent", "freez…
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "balanced", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens"…
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide AP.
Regulatory Flags
barrier-lipid
ceramide
alpha-hydroxy-ceramide
phytosphingosine-backbone
trilipid-triad
3:1:1-elias-ratio
atopic-dermatitis-target
scorad-improvement
steroid-sparing
peds-fda-510k
cir-reviewed
Frequently Asked Questions
Is Ceramide AP allowed in the EU?
Ceramide AP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide AP do in cosmetics?
Ceramide AP functions as: Ceramide barrier lipid, skin-conditioning agent. Part of ceramide:cholesterol:fatty acid triple-lipid system. Strengthens skin barrier, reduces water loss, supports healthy skin.. It is classified as a cosmetic ingredient in our database. CAS number: 154756-45-3.
Compliance Tools
Check Ceramide AP compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Ceramide EOP
Excellent
Same category
Ceramide 1 (acylceramide with linolei...
Ceramide NP
Excellent
Same category
Skin-conditioning agent, ceramide bar...
Sphingosine
Excellent
Same category
Skin-conditioning agent–miscellaneous...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
CETETH-10
Good
Browse nearby
Surfactant - Cleansing, Surfactant - ...
CETETH-2
Good
Browse nearby
Surfactant - Emulsifying
CETRARIA ISLANDICA THALLUS/POLYPODIUM VULGARE RHIZOME/SPHAGNUM MAGELLANICUM EXTRACT
Good
Browse nearby
Humectant, Skin Conditioning
CHAMOMILLA RECUTITA FLOWER/LAVANDULA ANGUSTIFOLIA FLOWER/MELISSA OFFICINALIS LEAF/ROSMARINUS OFFICINALIS LEAF/SALVIA OFFICINALIS LEAF EXTRACT
Good
Browse nearby
Skin Conditioning
(20S)-Protopanaxadiol
Moderate
Same EU status
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Same EU status
Anti-sebum, Antioxidant, Skin Protecting
Is Ceramide AP in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ceramide AP in your formulation.