Moderate Cosmetic Ingredient Sensitization Data

Carvone

INCI: CARVONE

Carvone (CAS 99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone)) is a cosmetic cosmetic ingredient functioning as Perfuming, denaturant, fragrance allergen. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.

View industrial chemical safety profile for CAS 99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone) →

Auto-generated CPSR Part A draft with source citations
CAS Number
99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone)
View industrial chemical safety profile →
Function
Perfuming, denaturant, fragrance allergen
Safety Rating
MODERATE

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes GRAS (21 CFR 182.60; FEMA 2249)

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Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Carvone.

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Sensitization Profile

Contact sensitization data for Carvone based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: SCCS Opinion

IFRA Concentration Limits (12 Product Categories)

International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.

Category Max % Category Max %
1 (Lip products) 0.26% 7a (Deodorant – not spray) 0.26%
2 (Body spray) 0.078% 7b (Deodorant spray) 0.26%
3 (Body cream) 0.26% 8 (Face cream) 0.086%
4 (Fine fragrance) 1.0% 9 (Soap) 0.52%
5a (Body lotion) 0.26% 10a (Household – non-spray) 0.52%
5b (Face cream leave-on) 0.26% 10b (Household – spray) No Restriction%
5c (Hand cream) 0.26% 11a (Intimate – leave-on) 0.086%
5d (Baby cream) 0.086% 11b (Intimate – rinse) 0.086%
6 (Mouthwash) 0.26% 12 (Not for consumer exposure) No Restriction%

Additional Ingredient Properties

2 property records from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS/1459/11"}
fragrance_ifra
{"cas_number": "99-49-0", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_pot…

Expert Verdict

Expert safety assessment and concern-level summary for Carvone.

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Carvone safe in cosmetics?

Carvone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.

Is Carvone allowed in the EU?

Carvone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Carvone do in cosmetics?

Carvone functions as: Perfuming, denaturant, fragrance allergen. It is classified as a cosmetic ingredient in our database. CAS number: 99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone).

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