NOAEL Studies Cosmetic Ingredient

Caramel NOAEL Studies

INCI: CARAMEL

CAS: 8028-89-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 400 mg/kg bw/day rat oral 70 day Immunotoxicology US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL >=25 g/kg bw/day Rat oral: drinking water 21 days reproduction toxicity EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =30 g/kg bw/day Rat oral: drinking water 91 days subchronic EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =20 g/kg bw/day Rat - 90 days subchronic EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL >=25 g/kg bw/day Rat oral: drinking water 21 days reproduction toxicity EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =30 g/kg bw/day Rat oral: drinking water 91 days subchronic EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =20 g/kg bw/day Rat - 90 days subchronic EFSA ANS - 2011 - OutputID 480 - no adverse effect observed at single/highest dose - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =100 mg/kg bw/day Consumers - - ADI EFSA ANS - 2011 - OutputID 480 - Consumers - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =100 mg/kg bw/day Consumers - - ADI EFSA ANS - 2011 - OutputID 480 - Consumers - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =300 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2011 - OutputID 480 - Consumers - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =300 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2011 - OutputID 480 - Consumers - Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives - doi:10.2903/j.efsa.2011.2004
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =20 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc00e4b0a7c65d22885a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4323?documentUUID=c72530dc-f612-4c28-b46f-f9b673d78f6d; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15842930:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9bbda0139f97d4cd7b68e6205044e72
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cba9e4b0a7c65d22711a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4323?documentUUID=c72530dc-f612-4c28-b46f-f9b673d78f6d; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843571_15843572:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_84c309a72492f066d63129cfa2ed597f
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cba9e4b0a7c65d22711a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4323?documentUUID=c72530dc-f612-4c28-b46f-f9b673d78f6d; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843571_15843572:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd6f9b6d536ffa8d6e1251d538452429
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =20000 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA ANS (2011). Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives. doi:10.2903/j.efsa.2011.2004.; TITLE=Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2011.2004; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614350:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edc3e383c812c1f2c02d8eb34b500182
ToxValDB_WHO_JECFA_ADI 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=200 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af99fe4b0d99f5a878379; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/436; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=WHO JECFA ADI:15715270:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db46282dbeba20befeb7c9c9760ad614
ToxValDB_WHO_JECFA_ADI ADI <=160 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb94e4b0d99f5a87b2a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/424; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=WHO JECFA ADI:15715368:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af554a9f7c15e28aa2d739b14a0910d6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T9D99G2B1R UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T9D99G2B1R"}
openFDA substances FDA UNII substance identifier T9D99G2B1R UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T9D99G2B1R"}
openFDA substances FDA UNII substance identifier T9D99G2B1R UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T9D99G2B1R"}
openFDA substances FDA UNII substance identifier T9D99G2B1R UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"T9D99G2B1R"}