Good Cosmetic Ingredient NOAEL Data

CAMELLIA SINENSIS SEED EXTRACT

Also known as: Camellia sinensis extract, Camellia thea extract

CAMELLIA SINENSIS SEED EXTRACT (CAS 84650-60-2) is a cosmetic cosmetic ingredient functioning as Humectant, Perfuming, Skin Conditioning. Reported NOAEL =100 mg/kg/d (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.

View industrial chemical safety profile for CAS 84650-60-2 →

Auto-generated CPSR Part A draft with source citations
Function
Humectant, Perfuming, Skin Conditioning
Safety Rating
GOOD

Chemistry & Identifiers

Regulatory Status

EU EU Status permitted
US US Status restricted
US Notes CIR: UNS - IJT 38(S3):48-70,2019

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for CAMELLIA SINENSIS SEED EXTRACT. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =100 mg/kg/d oral - oral toxicity CIR_vision_codex
NOAEL =100 mg/kg/d oral - oral toxicity CIR_vision_codex
NOAEL =100 mg/kg/d oral - oral toxicity CIR_vision_codex
NOAEL =100 mg/kg/d oral - oral toxicity CIR_vision_codex
NOAEL =200 mg/kg body weight oral - oral toxicity CIR_vision_codex
NOAEL =200 mg/kg body weight oral - oral toxicity CIR_vision_codex
NOAEL =200 mg/kg body weight oral - oral toxicity CIR_vision_codex
NOAEL =200 mg/kg body weight oral - oral toxicity CIR_vision_codex

Additional Ingredient Properties

1 property record from structured ingredient metadata.

anti_pollution
{"cas_number": "223749-100-1", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modula…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Antioxidant Astringent Biocide Bleaching agent Deodorizer Flavouring and nutrient Fragrance Humectant Pharmaceutical Softener and conditioner
Regulatory List Membership (3)
EU Regulated in Personal Care EU Restricted for Children (Cosmetics) FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for CAMELLIA SINENSIS SEED EXTRACT.

Regulatory Flags

cosing-sourced eu-permitted skin-conditioning humectant fragrance needs-enrichment eu_children_restricted fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to CAMELLIA SINENSIS SEED EXTRACT by CAS number or substance name.

Studies
8
Lowest NOAEL
100
Highest NOAEL
200

Units vary across source rows: mg/kg body weight, mg/kg/d

CIR_vision_codex

Known Synonyms

Camellia sinensis extract Camellia thea extract

Chemical Function

Humectant Softener and conditioner Biocide UV stabilizer Antioxidant Astringent Deodorizer

Regulatory Lists

children; Europe; Personal care children; Europe; Personal care - dental care - toothpaste Europe; Personal care Europe; Personal care Europe; Personal care food_additive; Substances Added to Food (formerly EAFUS) (2/2019)

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
sinecatechins
ChEMBL ID
CHEMBL1201723
View full pharmaceutical profile →

Frequently Asked Questions

Is CAMELLIA SINENSIS SEED EXTRACT safe in cosmetics?

CAMELLIA SINENSIS SEED EXTRACT has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 8 toxicological study endpoint(s) are available in our database.

Is CAMELLIA SINENSIS SEED EXTRACT allowed in the EU?

CAMELLIA SINENSIS SEED EXTRACT EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CAMELLIA SINENSIS SEED EXTRACT do in cosmetics?

CAMELLIA SINENSIS SEED EXTRACT functions as: Humectant, Perfuming, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84650-60-2.

What is the NOAEL for CAMELLIA SINENSIS SEED EXTRACT?

The NOAEL (No Observed Adverse Effect Level) for CAMELLIA SINENSIS SEED EXTRACT is =100 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR_vision_codex.

Is CAMELLIA SINENSIS SEED EXTRACT used outside cosmetics?

CAMELLIA SINENSIS SEED EXTRACT also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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