NOAEL Studies Cosmetic Ingredient

Calcium Benzoate NOAEL Studies

INCI: CALCIUM BENZOATE

CAS: 2090-05-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed - reproduction toxicity EFSA ANS - 2016 - OutputID 2794 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1310 mg/kg bw/day Rat oral: feed - reproduction toxicity EFSA ANS - 2016 - OutputID 2794 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed - reproduction toxicity EFSA ANS - 2016 - OutputID 2794 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1310 mg/kg bw/day Rat oral: feed - reproduction toxicity EFSA ANS - 2016 - OutputID 2794 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =5 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2016 - OutputID 2794 - Consumers - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =5 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2016 - OutputID 2794 - Consumers - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral short-term; 5 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cad6e4b0a7c65d223ae1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24934/7/6/2?documentUUID=11d691ad-8c1b-4c0d-9f47-9c18d29c10a5; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|histopathology: non-neoplastic|organ weights and organ / body weight ratios|serum/plasma biochemistry|serum/plasma hormone analyses; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15839335:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad6b664e3cc4ed1b72a5a6bdad824f78
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =1310 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=EFSA ANS (2016). Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives. doi:10.2903/j.efsa.2016.4433.; TITLE=Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4433; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15624469:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2280507d99d32db1ef760deb73e6e7f4
ToxValDB_EFSA NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=EFSA ANS (2016). Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives. doi:10.2903/j.efsa.2016.4433.; TITLE=Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4433; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15624470:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96430064240da4d58c97b427278a8803
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb5ee4b0d99f5a87ad24; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/452; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=WHO JECFA ADI:15715369:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0de026849e2430a4d57ff3ed971a78ae
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3QDE968MKD UNII - - - chemical {"approval_status":null,"molecular_formula":"2C7H5O2.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3QDE968MKD"}
openFDA substances FDA UNII substance identifier 3QDE968MKD UNII - - - chemical {"approval_status":null,"molecular_formula":"2C7H5O2.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3QDE968MKD"}
openFDA substances FDA UNII substance identifier 3QDE968MKD UNII - - - chemical {"approval_status":null,"molecular_formula":"2C7H5O2.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3QDE968MKD"}
openFDA substances FDA UNII substance identifier 3QDE968MKD UNII - - - chemical {"approval_status":null,"molecular_formula":"2C7H5O2.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3QDE968MKD"}