Is Calcium Aspartate safe in cosmetics?
Calcium Aspartate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Calcium Aspartate
INCI: CALCIUM ASPARTATE
Calcium Aspartate (CAS 21059-46-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. Reported NOAEL =700 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 21059-46-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate — Very low reported use concentrations (≤0.0005%)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Aspartate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Calcium Aspartate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =700 mg/kg bw/day | oral: feed | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =700 mg/kg bw/day | oral: feed | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Aspartate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Calcium Aspartate by CAS number or substance name.
Studies
2
Lowest NOAEL
700 mg/kg bw/day
Highest NOAEL
700 mg/kg bw/day
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Calcium Aspartate allowed in the EU?
Calcium Aspartate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Aspartate do in cosmetics?
Calcium Aspartate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 21059-46-1.
What is the NOAEL for Calcium Aspartate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Aspartate is =700 mg/kg bw/day based on a subchronic study via oral: feed route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Compliance Tools
Check Calcium Aspartate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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