Is C18-21 Alkane safe in cosmetics?
C18-21 Alkane has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
C18-21 Alkane
Also known as: Hydrotreated middle distillate (petroleum), Distillates (petroleum), straight run middle, hydrotreated, Amoco NT-45 process oil, EINECS 265-148-2, UNII-114P5I43UJ
INCI: C18-21 ALKANE
C18-21 Alkane (CAS 64742-46-7) is a cosmetic cosmetic ingredient functioning as Solvent; Fragrance Functional (excipient of perfume oils). Reported NOAEL =750 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 64742-46-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
C18-21 Alkane is classified GHS Danger (H226, H304, H315, H332, H350, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent; Fragrance Functional (excipient of perfume oils)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not individually calculated; read-across from mineral hydrocarbon safety data supports adequate MoS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for C18-21 Alkane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for C18-21 Alkane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =750 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Carc. 1B
Hazard Statements
- H350 May cause cancer
Inserted via ATP: ATP02
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000,000 - 100,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 875
(EC) 2009/1223
CMR: Carcinogenic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive
Defoamer
Diluent
Fragrance
Processing aids not otherwise specified
Softener and conditioner
Solvent
Viscosity modifier
Regulatory List Membership (3)
EU Banned in Cosmetics
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for C18-21 Alkane.
Regulatory Flags
fragrance-component
eu_banned_cosmetics
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to C18-21 Alkane by CAS number or substance name.
Studies
1
Lowest NOAEL
750 mg/kg bw/day
Highest NOAEL
750 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Hydrotreated middle distillate (petroleum)
Distillates (petroleum), straight run middle, hydrotreated
Amoco NT-45 process oil
EINECS 265-148-2
UNII-114P5I43UJ
Chemical Function
Solvent
Viscosity modifier
Softener and conditioner
Anti-adhesive/cohesive
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
banned; Europe; Personal care
IFRA Transparency
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is C18-21 Alkane allowed in the EU?
C18-21 Alkane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does C18-21 Alkane do in cosmetics?
C18-21 Alkane functions as: Solvent; Fragrance Functional (excipient of perfume oils). It is classified as a cosmetic ingredient in our database. CAS number: 64742-46-7.
What is the NOAEL for C18-21 Alkane?
The NOAEL (No Observed Adverse Effect Level) for C18-21 Alkane is =750 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is C18-21 Alkane used outside cosmetics?
C18-21 Alkane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does C18-21 Alkane have different safety status in cosmetics vs industrial chemicals?
C18-21 Alkane is classified GHS Danger (H226, H304, H315, H332, H350, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check C18-21 Alkane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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