Is Butyl Laevulinate safe in cosmetics?
Butyl Laevulinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Butyl Laevulinate
Also known as: Butyl levulinate, Pentanoic acid, 4-oxo-, butyl ester, 4-03-00-01563, BRN 1768453, Butyl acetylpropionate (+8 more)
INCI: BUTYL LAEVULINATE
Butyl Laevulinate (CAS 2052-15-5) is a cosmetic cosmetic ingredient functioning as Fragrance, Solvent, Masking agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2052-15-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Solvent, Masking agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl 4-oxopentanoate
InChIKey
ISBWNEKJSSLXOD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Likely favorable — read-across from levulinic acid and butanol toxicological profiles. Standalone MoS calculation not published.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Laevulinate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
608
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL LEVULINATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Laevulinate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Butyl levulinate
Pentanoic acid, 4-oxo-, butyl ester
4-03-00-01563
BRN 1768453
Butyl acetylpropionate
Butyl 4-ketovalerate
n-Butyl laevulinate
n-Butyl levulinate
EINECS 218-143-4
FEMA No. 2207
4-Ketopentanoic acid butyl ester
NSC 78451
UNII-OI56208RTB
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188634
Frequently Asked Questions
Is Butyl Laevulinate allowed in the EU?
Butyl Laevulinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Laevulinate do in cosmetics?
Butyl Laevulinate functions as: Fragrance, Solvent, Masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 2052-15-5.
Is Butyl Laevulinate used outside cosmetics?
Butyl Laevulinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Laevulinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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